62 
C. CONTROLS. 
Date. 
Weight 
of mouse. 
Remarks. 
190S. 
February 11 
Ii98 
Feeding of cakes without thyroid commenced. 
14. . . . 
13.91 
17.... 
14.26 
20.... 
13. 75 
21 1 
14.33 
Acetonitrile, 4.59 mgms., i. e., 0.32 mgm. per gm. mouse. Surrived. 
February 11 
19. 48 
Cakes as aboye. 
‘ 14.... 
17.70 
17.... 
17.45 
20.... 
16.90 
21.... 
17.42 i 
Acetonitrile, 6.62 mgms., i. e., 0.38 mgm. per gm. mouse. Surrired. 
February 11 
14.98 
Cakes as aboye. 
14. . . . 
13.08 
17.... 
12.72 
20.... 
12.85 
21.... 
13.04 
Acetonitrile, 7.17 mgms., i. e., 0.55 mgm. per gm. mouse. Died 41 hours. . 
Summary . — The results of the above experiments may be sum- 
marized as follows: 
Gmthy- ! 
roid fed 
daily. 
Percentage 
of iodine 
! in thyroid. 
Mgm. I in 
thyroid fed 
daily. 
Fatal dose of ace- 
tonitrile in mgm. 
per gm. 
Recovered. 
Died. 
A 
a 001 
0.1 
0.0010 
1.6 
2.1 
B 
.001 
.19 
.0019 
ao 
ay 
C. Controls 
.38 
• oo 
Series VI. 
In this series the effects of a number of commercial thyroid powders 
with different percentages of iodine were compared; the effects of 
different amounts were also compared. 
A. SHEEP THYROID; 0.11 PER CENT IODINE. 
Date. 
Weight 
of mouse. 
Remarks. 
1908. 
April 8 
13.41 
Feeding of cakes each containing 0.001 gm. thyroid commenced. 
11 
12.68 
14. 
13.32 | 
16 
13.25 
Acetonitrile, 26.50 mgms., i. e., 2 mgms. per gm. mouse. Surriyed 
April 8 
12.82 ' 
Thyroid as above. 
11 
12,30 : 
14 
13.26 
16 
13.22 
17 
13.13 ( 
Acetonitrile, a2.83 mgms., i. e., 2.5 mgms. per gm. mouse. Survived. 
April 8 
14.63 ' 
Thyroid as above. 
11 
14.72 
14 
14 06 
16 
13.54 
17 . 
13.22 
Acetonitrile, 39.66 mgms., i. e., 3 mgms. per gm. mouse. Died 10 hours. 
April 8 
13.17 
Thyroid as above. 
11 
ia50 
14 
12.90 
17 
13.02 
Acetonitrile, 45.57 mgms., i. e,, 3.5 mgms. per gm. mouse. Died 11 hours. 
