74 
D. SHEEP THYROID; 0.11 PER CENT IODINE. 
Date. 
Weight 
of rat. 
1908. 
June 27 
33 
July 1 
32 
6 
30 
June 27 
29 
July 1 
30 
6 
30 
7 
June 27 
46 
July 1 
42 
6 
45 
7 
June 27 
58 
July 1 
57 
6 
55 
Remarks. 
Feeding of cakes each containing 0.0005 gm. thyroid commenced. 
Acetonitrile, 45 mgms., i. e., 1.5 mgms. per gm. rat. Survived. 
Thyroid as above. 
Acetonitrile, 48 mgms., i. e., 1.6 mgms. per gm. rat. Survived. 
Thyroid as above. 
Acetonitrile, 81 mgms., i. e., 1.8 mgms. per gm. rat. Died 4f hours. 
Thyroid as above. 
Acetonitrile, 104.5 mgms., i. e., 1.9 mgms. per gm. rat. Died 1| hours. 
E. CONTROLS. 
1908. 
June 27 
34 
Feeding of cakes without thyroid commenced. 
July 1 
33 
6 
34 
Acetonitrile, 102 mgms., i. e., 3 mgms. per gm. rat. Survived. 
Feeding of cakes as above. 
■Tune 27 
30 
July 1 
31 
6 
30 
7 
Acetonitrile, 99 mgms., i. e., 3.3 mgms. per gm. rat. Survived. 
Cakes as above. 
June 27 
31 
July 1 
29 
6 
29 
7 
Acetonitrile, 104.4, mgms., i. e., 3.6 mgms. per gm. rat. Survived. 
Cakes as above. 
June 27 
52 
July 1 
49 
6 
49 
7 
Acetonitrile, 196 mgms., i. e., 4 mgms. per gm. rat. Died 4 hours. 
Summary . — The above results may be tabulated as follows: 
Gm. thy- 
roid in 
each cake. 
Percentage 
of iodine 
in thyroid. 
Mgm. I in 
thyroid in 
each cake. 
Fatal dose of aceto- 
nitrile in mgms. 
per gm. 
Recovered. 
Died. 
A 
0.001 
0.085 
0.00085 
1.4 
1.7 
B 
.001 
.11 
.0011 
1.0 
1.1 
c 
.001 
.21 
.0021 
.55 
.7 
D 
.0005 
.1! 
.00055 
1.6 
1.8 
E . Controls 
3.6 
4.0 
