79 
B. HOG THYROID; 0.33 PER CENT IODINE. 
Date. 
Weight 
of rat. 
Remarks. 
1907. 
May 30 
78 
Feeding of cakes each containing 0.005 gm. thyroid begun. 
June 3 
71 
7 
9 
72 
67 
Morphine sulphate, 1.68 mgms., i. e., 0.025 mgm. per gm. rat. Survived. 
May 30 
77 
Thyroid as above. 
June 3 
72 
7 
70 
9 
68 
Morphine sulphate, 2.72 mgms., i. e., 0.04 mgm. per gm. rat. Died in 3 horns. 
May 30. . 
101 
Thyroid as above. 
June 3 
97 
7 
89 
9 
90 
Morphine sulphate, 4.5 mgms., i. e., 0.05 mgm. per gm. rat. Died 1| hours. 
C. CONTROLS. 
1907. 
May 30 
93 
Feeding of plain cakes begun. 
June 3 
91 
7 
91 
9 
91 
Morphine sulphate, 27.3 mgms., i. e., 0.3 mgm. per gm. rat. Survived. 
May 30 
79 
Cakes as above. 
June 3 
75 
7 
73 
9 
74 
Morphine sulphate, 25.9 mgms., i. e., 0.35 mgm. per gm. rat. Survived. 
May 30 
92 
Cakes as above. 
June 3 
83 
7 
82 
9 
80 
Morphine sulphate, 32.0 mgms., i. e., 0.4 mgm. per gm. rat. Survived. 
June 1 
46 
Cakes as above. 
5 
45 
7 
45 
11.. 
43 
Morphine sulphate, 18.06 mgms., i. e., 0.42 mgm. per gm. rat. Died 2 hours. 
Summary . — The results of these experiments may be summarized 
as follows: 
Gm. thy- 
roid in each 
cake. 
Percentage 
of iodine 
in thyroid. 
Mgm. I in 
thyroid of 
each cake. 
Average 
loss of 
weight in 
per cent of 
original 
weight. 
Fatal dose of mor- 
phine in mg. per 
gm. 
Recovered. 
Died. 
A... 
0. 005 
. 005 
0. 176 
.33 
9.0088 
.0165 
ia4 
12.1 
7.1 
0.07 
.025 
.40 
B 
0.04 
.42 
C. Controls 
Unfortunately the fatal dose of morphine for rats which had 
received sheep thyroid. A, was not determined; it was probably 
twice as great as that for those which had received hog thyroids, B. 
The sheep thyroid contained about one-half as much iodine as the 
hog thyroid. Rats receiving the hog thyroid died from one-tenth 
the amount of morphine necessary to kill the controls. The rats of 
