83 
Series IY. 
The following experiments may be quoted for the purpose of 
illustrating how markedly the resistance of rats to morphine may be 
reduced by the feeding of thyroid rather than because they bring out 
the effects of different iodine percentages. The amounts of thyroid 
fed were selected so as to make the total amount of iodine approxi- 
mately equal in all cases. Unfortunately the experiments were not 
sufficiently numerous for us to determine the minimum lethal doses 
in all cases. 
A. DOG THYROIDS; 0.111 PER CENT IODINE. 
Date. 
Weight 
of rat. 
Remarks. 
1907. 
June 25 
189 
Feeding of cakes each containing 0.003 gm. thyroid begun. 
29 
181 
July 3 
181 
5 
182 
Morphine sulphate, 7.28 mgms., i. e., 0.04 mgm. per gm. rat. Died 13 hours. 
June 25 
192 
Thyroid as above. 
29 
186 
July 3 
183 
6 
176 
Morphine sulphate, 9.68 mgms., i. e., 0.055 mgm. per gm. rat. Died 4 hours. 
June 25 
152 
Thyroid as above. 
29 
142 
July 3 
138 
5 
138 
Morphine sulphate, 9.66 mgms., i. e., 0.07 mgm. per gm. rat. Died 9 hours. 
B. THYROID OF GUINEA PIG; 0.05 PER CENT IODINE. 
1907. 
June 25 
116 
Feeding of cakes each containing 0.007 gm. thyroid begun. 
29 
117 
July 3.. . 
118 
5 
118 
Morphine sulphate, 10.62 mgms., i. e., 0.09 mgm. per gm. rat. Survived. 
June 25 
156 
Thyroid as above. 
29........ 
155 
July 3 
155 
5 
156 
Morphine sulphate, 15.63 mgms., i. e., 0.1 mgm. per gm. rat. Died 3J hours. 
June 25 
106 
Thyroid as above. 
29 
101 
July 3 
100 
5 
101 
Morphine sulphate, 12.12 mgms., i. e., 0.12 mgm. per gm. rat. Died 4J hours. 
C. HOG THYROID; 0.33 PER CENT IODINE. 
1907. 
June 25 
141 
Feeding of cakes each containing 0.001 gm. thyroid begun. 
29 
134 
July 3 
133 
5 
133 
Morphine sulphate, 3.99 mgms., i. e., 0.03 mgm. per gm. rat. Died 2|- hours. 
June 25 
138 
Thyroid as above. 
29 
134 
July3 
135 
Morphine sulphate, 5.28 mgms., i. e., 0.04 mgm, per gm. rat. Died 2f hours. 
5 
132 
J,une 25 
29 
July 3 
155 
' 149 
146 
Thyroid as above. 
Morphine sulphate, 8.7 mgms., i. e., 0.06 mgm. per gm. rat. Died 2 hours. 
5 
145 
