86 
SERIES I.— SHEEP THYROID. 
Gm. tny- 
roid fed 
daily. 
Percentage 
of iodine 
in thyroid. 
Mgm. I in 
thyroid fed 
daily. 
Fatal dose of morphine 
in mgm. per gm. 
Recovered. Died. 
Loss in 
weight in 
percentage 
of original 
weight. 
A 
0.001 
0.085 
0.00085 
0.17 
0.25 
9.0 
B 
.001 
.11 
.0011 
.09 
.11 
14.3 
C 
.001 
.11 
.0011 
. 12“ 
.16 
3.7 
D 
.001 
.19 
.0019 
.12 
.14 
10.7 
E 
.001 
.21 
.0021 
.13 
.16 
14.6 
F. Controls 
.19 
.20 
9.9 
The resistance of mice to morphine was uniformly diminished by 
the thyroid. The thyroid haring the least effect was the prepara- 
tion containing the smallest percentage of iodine: the effects of the 
other preparations were nearly equal, although some contained 
nearly twice as much iodine as others. There was no constant 
relation between the loss of weight and the diminished resistance to 
morp hin e. 
series n. 
Gm. thy- Percentage 
roid fed of iodine 
daily. in thyroid. 
Mgm. I in 
thyroid 
fed daily. 1 
Fatal dose in mgm. 
per gm. 
Recovered. Died. 
Loss in 
weight. 
1 
0.005 
0.085 
0.00425 
0.17 
0.18 
8. 6 
B 
.005 
.n j 
.0055 | 
.08 
-11 
13.2 
C 
.005 
.19 | 
. 0095 
.09 
.10 
8.8 
D 
. 005 
.21 
.0105 : 
.07 
.09 
23.5 
E 
-01 
.1 ! 
.01 
.10 
.12 
15.1 
F 
.01 
.11 i 
.on [ 
.13 i 
.14 
16.5 
G 
.01 
.11 ! 
.011 
.105 
.12 
13.6 
H 
.01 
. 11 
.011 I 
.13 
.16 
14.2 
I 
.01 
.19 
.019 
.08 
.09 
15.0 
J 
.01 
.21 
.021 
.03 
.08 
9.4 
K. Controls... 
.17 
.18 
7.5 
The thyroid with the largest percentage of iodine was the most 
active when the smaller (0.005 gm.) as well as when the larger 
(0.01 gm.) amounts of thyroid were fed. In some cases the loss of 
weight was parallel with the increased susceptibility to morphine; 
in other cases it was not. 
series III. 
Gm. thv- 
Percemage 
of iodine 
Mgna. I in 
thvroid 
Fatal dose in mgm. 
per gm. 
Loss in 
daily. 
in thyroid. 
fed daily. 
Recovered. 
Died. 
w eigni .« 
\ 
0.01 
0.05 
0.005 
0.18 
0.22 
4- 3.0 
B 
01 
.104 
.0104 
.11 
.16 
5.8 
C 
.01 
.19 
.0190 
.09 
18.0 
D 
.01 
.298 
.0298 
.09 
.10 
11.7 
E 
.01 
.33 
.0330 
.07 
.09 
2.4 
F. Controls 
,43 
. 45 
4- &7 
a The -f sign indicates that the mice had increased in weight. 
