89 
Series II. 
A. SHEEP THYROID; 0.084 PER CENT IODINE. 
Date. 
Weight 
of pig. 
Remarks. 
1907. 
April 4 
265 
Feeding of thyroid, 0.24 gm. daily, begun. 
8 
232 
12 
220 
16 
195 
Morphine sulphate, 48.75 mgms., i. e., 0.25 mgm. Died 10 to 15 hours. 
April 4 
244 
Thyroid as above. 
8 
235 
12 
255 
14 
256 
Morphine sulphate, 76.8 mgms., i. e., 0.3 mgm. per gm. pig. Died 21 hours. 
April 4 
260 
Thyroid as above. 
8 
225 
12 
215 
14 
217 
Morphine sulphate, 108.5 mgms., i. e., 0.5 mgm. per gm. pig. Died 4 hours. 
B. CONTROLS. 
1907. 
April 4 
250 
8 
270 
12 
300 
14 
302 
Morphine sulphate, 196.3 mgms., i. e., 0.65 mgm. per gm. pig. Survived. 
April 4 
252 
8 
280 
12 
315 
15 
335 
Morphine sulphate, 251.25 mgms., i. e., 0.75 mgm. per gm. pig. Died 3 J hours. 
April 4 
240 
8 
275 
12 
290 
- 14 
307 
Morphine sulphate, 245.6 mgms., i. e., 0.8 mgm. Died 2 hours. 
Summary. The results of the above experiments may be sum- 
marized as follows: 
Gm. 
thyroid 
fed daily. 
Percentage 
of iodine 
in thy- 
roid. 
Mgm. I in 
thyroid 
fed daily. 
Fatal dose in mgm. per 
gm. 
Average 
loss of 
weight in 
per cent of 
original 
. weight.® 
Recovered. 
Died. 
Series I 
Controls 
0.12 
0.084 
0. 1008 
0.2 
.5 
. 65 
0.25 
.60 
.25 
.75 
7.9 
+21.2 
13.1 
+27.2 
Series II .24 
Controls 
.084 
.2016 
a The + sign indicates that the guinea-pigs had increased in weight. 
The guinea pigs which had received the thyroid died from one- 
third to one-half of the dose of morphine fatal to the controls. The 
amount of thyroid fed was very large and the animals were evidently 
deeply intoxicated. 
