99 
Summary . — The results of the foregoing experiments may be tabu- 
lated as follows: 
Gm. thy- 
roid fed 
daily. 
Percentage 
of iodine in 
thyroid. 
Mgm. I in 
thyroid fed 
daily. 
Fatal dose of ace- 
tonitrile in mgms. 
per gm. 
Recovered. 
Died. 
A 
0.003 
0. 106 
0. 00318 
2.5 
2.7 
B . . 
.002 
.148 
. 00296 
2.9 
2. 9 
C 
.001 
.300 
.0030 
3.0 
2. 9 
D 
.002 
.300 
.0060 
4. 4 
5.0 
E. Controls 
.72 
.75 
Thyroid containing 0.106, 0.148, and 0.3 per cent iodine, respec- 
tively, was fed to mice. When fed in amounts corresponding to the 
ratio of 3, 2, and 1 (namely, in the inverse ratio to the iodine content) 
the physiological effects were approximately equal. With equal 
amounts of the thyroid containing 0.148 and 0.3 per cent iodine the 
latter was much the more active. 
Series III. 
In the following experiments the effects of the thyroid of Group 3 
(normal; 0.106 per cent iodine) and of Group 5 (iodoform fed dogs; 
0.3 per cent iodine) were compared. 
A. THYROID OF GROUP 3 (NORMAL); 0.106 PER CENT IODINE. 
Date. 
Weight. 
1908. 
April 25 
18.45 
29 
19.74 
May 2 
19.74 
3 
19.74 
April 25 
15.00 
29 
15.16 
May 2 
15.14 
4 
15.28 
5 
April 25 
15.73 
29 
14.88 
May 2 
14. 50 
4 
14. 34 
April 25 
16. 87 
29 
18.20 
May 2 
17. 60 
4 
18. 15 
Remarks. 
Feeding of cakes each containing 0.0005 gm. thyroid commenced. 
Acetonitrile, 35.53 mgms., i. e., 1.8 mgms. per gm. mouse. Survived. 
Thyroid as above. 
Acetonitrile, 29.03 mgms., i. e., 1.9 mgms. per gm. mouse. Survived. 
Thyroid as above. 
Acetonitrile, 30.11 mgms., i. e., 2.1 mgms. per gm. mouse. Died 6 hours. 
Thyroid as above. 
Acetonitrile, 41.75 mgms., i. e., 2.3 mgms. per gm. mouse. Died 3§ hours. 
