101 
E. CONTROLS. 
Date. 
April 25. 
29. 
May 2. . . 
3... 
April 25. 
29. 
May 2... 
4.. . 
5.. . 
April 25. 
29. 
May 2. . . 
4.. . 
5.. . 
Weight. 
13. 45 
14.47 
14. 56 
14. 56 
18.43 
19. 67 
19.76 
19.54 
16.88 
15. 43 
15. 57 
15.21 
Remarks. 
Feeding of cakes without thyroid commenced. 
Acetonitrile, 7.43 mgms., i. e., 0.51 mgm. per gm. mouse. Survived. 
Cakes as above. 
Acetonitrile, 10.16 mgms., i. e., 0.52 mgm. per gm. mouse. Died 1 hour. 
% 
Cakes as above. 
Acetonitrile, 8.06 mgms., i. e., 0.53 mgm. per gm. mouse. Died 8 hours. 
Summary . — The results of the above experiments may be tabu- 
lated as follows: 
Gm. 
thyroid 
fed daily. 
Percentage 
of iodine 
in thyroid. 
Mgm. I in 
thyroid 
fed daily. 
Fatal dose of ace- 
tonitrile in mgms. 
per gm. 
Recovered. 
Died. 
A 
B 
C 
D 
E. Controls 
0.0005 
.0015 
.0005 
.001 
0. 106 
.106 
.300 
.300 * 
0.00053 
. 00159 | 
. 00150 : 
.00300 
1.9 
3.1 
3.7 
4.1 
.51 
2.1 
3.6 
4.2 
4.7 
.52 

With equal amounts of thyroid containing, respectively, 0.106 and 
0.3 per cent iodine, the effect of the latter was much greater than that 
of the former; with three parts of the former and one part of the 
latter the effects were nearly equal. One part of the thyroid rich in 
iodine was also much more active than one and one-half parts of the 
thyroid poor in iodine. 
