103 
D. (CONTROLS.) 
Date. 
Weight 
of mouse. 
Remarks. 
May 9 
16.65 
15 
16.06 
16 
16.05 
17 
May 9 
16. 50 
15 
15. 74 
16 
15.42 
18 
15. 56 
May 9. 
15.79 
15. . 
11.80 
16 
12. 15 
18 
13. 16 
Feeding of cakes without thyroid commenced. 
Acetonitrile, 5.78 mgms., i. e., 0.36 mgm. per gm. mouse. 
Cakes as above. 
Acetonitrile, 5.76 mgms., i. e., 0.37 mgm. per gm. mouse. 
Cakes as above. 
Acetonitrile, 5.27 mgms., i. e. 0.4 mgm. per gm. mouse. 
Survived. 
Died 2 hours. 
Died 4 hours. 
Summary . — The results of the above experiments may be summa- 
rized as follows: 
Gm. 
thyroid 
fed daily. 
Percentage 
of iodine 
in thyroid. 
Mgm. I in 
thyroid 
fed daily. 
Fatal dose of ace- 
tonitrile in mgms . 
per gm. 
Recovered. 
Died. 
A 
0. 0005 
0.111 
0. 00055 
1.1 
1.4 
B 
.0005 
.129 
.00064 
1.8 
2.1 
C 
TV Onntrftls 
.0005 
.300 
.00150 
3.1 
.36 
3.3 
.37 
The thyroid of the dogs which had received iodoform was much 
more active than that of the normal dogs. 
6. Experiments on Rats. 
Results very similar to the above were obtained in a series of 
experiments upon rats. In these animals there is a diminution of 
resistance to acetonitrile. 
A. THYROID OF GROUP 2 (NORMAL); 0.111 PER CENT IODINE. 
Date. 
Weight ! 
of rat. 
Remarks. 
1908. 
May 15 
32 
Feeding of cakes, each containing 0.0005 gm. thyroid, commenced. 
18 
33 
20 j 
33 
23 
32 
Acetonitrile, 51.2 mgms., i. e., 1.6 mgms. per gm. rat. Died about 17 hours. 
May 15 
43 
43 
Thyroid as above. 
20 
43 
23 
41 
24 
I Acetonitrile, 73.8 mgms., i. e.., 1.8 mgms. per gm. rat. Survived. 
May 15 
50 
Thyroid as above. 
18 
50 
20 
49 
23./. 
48 
Acetonitrile, 100.8 mgms., i. e., 2.1 mgms. per gm. rat. Died 2 hours. 
May 15 
35 
Thyroid as above. 
18 
34 
20 
34 
23 
32 
25 
32 
Acetonitrile, 70.4 mgms., i. e., 2.2 mgms. per gm. rat. Died 4 hours. 
