106 
With equal amounts of thyroid that containing the higher per- 
centage of iodine was the more active. To obtain approximately 
equal effects it was necessary to give three times as much of the 
thyroid poor in iodine as of the thyroid rich in iodine. 
2. EXPERIMENTS WITH MORPHINE. 
a. Experiments ox Mice. 
Only one short series of experiments was performed in which the 
effect of feeding the above thyroid preparations upon the resistance 
of mice to morphine sulphate was tested. 
The results indicate that the thyroid of the iodoform-fed dogs is 
distinctly more active in lowering the resistance of mice to morphine 
than is that of the normal dogs. 
A. THYROID OF GROUP 2 (NORMAL); 0.1H PER CENT IODINE. 
Date. 
W eight 
of mouse. 
Remarks. 
1907. 
July 3 
n.&4 
Feeding of cakes, each containing 0.01 jm. thyroid, commenced. 
8 
.... 11.71 I 
n 
.... n.io i 
13 
.... 10.40 
Morphine sulphate, 0.73 mgms., i 
. e., 0.07 mgm. per gm. mouse. Survived 
Julv 3 
.... 13.33 
Thyroid as above. 
8 
.... 13.64 
11 
14.45 
14 
.... 13.33 
Morphine sulphate, 1.47 mgms., i. e., 0.11 mgm. per gm. mouse. Survived. 
July 3 
.... 12.14 
Thyroid as above. 
8. : . . 
.... 12.77 
n 
12.05 
13 
Morphine sulphate, 1.8 mgms., i. 
e., 0.16 mgm. per gm. mouse. Died three- 
fourths hour. 
B. THYROID OF GROUP 5 (IODOFORM; 
i; OX PER CENT IODINE. 
1907. 
July 3 
.... 14.65 
Feeding of cakes, each containing 0.01 gm. thvroid. commenced. 
8 
.... 16.22 f 
12 
.... 13.00 
14 
.... 11.76 
Morphine sulphate, 0X2 mgm., i. 
e., 0.07 mgm. per gm. mouse. Survived. 
July 3 
12.92 
Thyroid as above. 
8 
.... 13.02 | 
12 
13.32 
14 
11.94 
Morphine sulphate, 1.07 mgms., i 
. e., 0.09 mgm. per gm. mouse. Survived. 
July 3 
.... 13.23 
Thyroid as above. 
8 
.... 13.10 
12 
.... 12.45 i 
13 
.... 12.32 
Morphine sulphate, 1.23 mgms., i, 
. e., 0.1 mgm. per gm. mouse. Died 2 hours 
