107 
C. CONTROLS. 
Date. 
Weight 
of mouse. 
Remarks. 
1907. 
July 3 
13. 30 
Feeding of cakes without thyroid commenced. 
8 
14.40 
12 
14.25 
Morphine sulphate, 5.27 mgms., i. e., 0.37 mgm. per gm. mouse. Survived. 
July 3 
11.40 
Cakes as above. 
8 
11.90 
12 
12.45 
13 
12.33 
Morphine sulphate, 5.18 mgms., i. e., 0.42 mgm. per gm. mouse. Survived. 
July 3 
14.25 
Cakes as above. 
8.; 
14.46 
12 
14.85 
14 
14.40 
Morphine sulphate, 6.19 mgms., i. e., 0.43 mgm. per gm. mouse. Survived. 
July 3 
12. 90 
Cakes as above. 
8 
15. 32 
12 
15. 72 
15 
15.40 
Morphine suipTiate, 6.93 mgms., i. e., 0.45 mgm. per gm. mouse. Died 1 \ hours 
July 3 
13.85 
Cakes as above. 
8 
12. 90 
12 
11.77 
14 
11.75 
Morphine sulphate, 5.4 mgms., i. e., 0.46 mgm. per gm. mouse. Died about 
hours. 
Summary . — The results of these experiments may be tabulated as 
follows : 
Gm. thy- 
roid fed 
daily. 
Percentage 
of iodine 
in thyroid. 
Mg. I in 
thyroid fed 
daily. 
Fatal dose of mor- 
phine sulphate in 
mgm. per gm. 
Recovered. 
Died. 
A 
0. 01 
.01 
0.111 
.300 
0. 0111 
.0300 
0. 11 
.09 
.43 
0. 16 
.10 
.45 
B 
C. Controls 
6. Experiments on Rats. 
The following series of experiments on rats, although very incom- 
plete, show that the activity of the thyroid, the iodine content of 
which has been increased by the administration of iodoform to dogs, 
was much greater than that of normal thyroid. 
Series I. 
A. THYROID OF GROUP 2 (NORMAL); 0.111 PER CENT IODINE. 
Date. 
Weight 
of rat. 
Remarks. 
1908. 
May 15 
43 
Feeding of cakes, each containing 0. 0005 gm. thyroid, commenced. 
18 
43 
20 
43 
23 
41 
27 
40 
Morphine sulphate, 10 mgms., i. e., 0.25 mgm. per gm. rat. Survived. 
