35 
Table I . — Determination of the minimum lethal dose 'per gram body weight for white 
mice; subcutaneous injection — Continued. 
SUMMARY. 
Minimum lethal dose for mice per gram body weight. 
Preparation. 
Milli- 
grams. 
Mulford (digitol) - 
4 
B. W. and Co. (concentrated tincture) 
4 
Merrell (normal tincture) 
6 
H. B. and W. (fluid extract) 
7 
P., D. and Co. (fluid extract) 
8 
N., B. and Co. (fluid extract) 
9 
S. and.D. (fluid extract) 
9 
Digitalone No. 1 (P., D. and Co.) 
22 
Lloyd Bros, (specific medicine) 
24 
Guinea pigs . — Guinea pigs of about the same weight were injected 
beneath the skin of the abdomen with the drugs to be tested. The 
dose was reckoned according to the weight of the animal and the 
preparations were so diluted as to make the bulk of the fluid injected 
between 1 and 2 c. c. The results of these experiments are recorded 
in Table II. 
Table III — Determination of the minimum lethal dose for guinea pigs — subcutaneous 
injection. 
[Survived = — : dead = +.] 
MULFORD NO. 1. 
Number of animals used. a 
Dose. 
Result. 
1 
mgm. 
0.56 
1 
.625 
_ 
2 
.65 
_ 
1 
.70 
_ 
1 . 
.70 
+ 
1 
. 75 
+ 
1 . 
.80 
+ 
MERRELL. 
1. 
0.40 
2 
.50 
_ 
4 
.50 
+ 
3 
.60 
5. 
.60 
+ 
i 
. 65 
2 
.70 
+ 
B. W. AND CO. 
LLOYD BROS. 
Number of animals used.® 
Dose. 
Result. 
mgm. 
0. 70 
2 
.80 
2 
.80 
+ . 
2 
.90 
.90 
1.00 
3 
+ 
1 
2 
1.00 
+ 
1 
1.50 
+ - 
1 
2.00 
1 
+ 
DIGIT ALONE NO. 1. 
* 
1 
2.00 - 
1 
4. 00 ! — 
16 
5.00 + 
N., B. AND CO. 
1 
! 0.25 
— 1 
0.50 
2 
.30 
— 1 
.70 
1 
.35 
- 2 
.80 
2 
.35 
+ 2 
.80 
+ 
1 
.40 
3 
.90 
+ 
1 
.55 
+ 2 
1.00 
+ 
1. 
.68 
+ 1 
1.20 
+ 
a This heading refers to the number of animals which received the dose indicated in the second column. 
b Guinea pig, weight 250 grams, injected with 12.5 c. c., digitalone No. 1. No digitalis symptoms what- 
ever appeared, the animal passing at once into a comatose condition. The respiration became weaker 
and finally ceased. Cause of death ( ? ). 
