39 
Table III . — Determination of blood pressure and minimum lethal dose for eats, 
intravenous injection. Fluid extracts diluted to 10 per cent strength — Continued. 
SUMMARY OF TOXIC DOSES FOR CATS (AVERAGES). 
B. W. and Co... 
P., D. and Co.. 
M., B. and Co .. 
Mulford No. 2. . . 
H. B. and W... 
S. and D 
Merrell 
Digital one No. 3. 
Lloyd Bros 
Digital one No. 2. 
Preparation. 
Milli- 
grams. 
158 
171 
192 
195 
219 
242 
252 
280 
438 
550 
Frogs . — Finally the toxic dose on frogs was found according to 
Houghton’s® method (see p. 16 ). The frogs (R. pipiens, Schreber, 
Syn. R. virescens and halecina) were unpacked as soon as they 
arrived and placed in a large cage through the end of which flowed 
fresh water. They were only brought to the experimental room 
when needed and injected late in the afternoon. They were then 
placed in separate jars and early the following morning the death 
or survival of each animal was noted. The results of experiments 
in which the lethal doses of four of the digitalis preparations were 
determined are given in Table IV. 
Table IV . — Determination of the minimum lethal dose for Dana pipiens, twelve-hour 
method. 
[Survived = — , dead = +. Dose per gram body weight.] 
MULFORD NO. 2. P., D. AND CO. 
Series. 
Dose. 
Result. Series. 
Dose. 
Result. 
c. c. 
c. c. 
1 
0. 016 
- l 
0. 024 
.018 
! 026 

.020 
+ 
.028 

2 
.019 
+ 2. 
.030 
4 - 
.020 
+ 
.032 
.020 
— 
.034 
+ 
3 
.020 
+ 3 
. 029 
_|_ 
.020 
+ 
!030 
+ 
.020 
‘ — 
.032 
+ 
4 
.029 
+ 
.029 
+ 
.029 
+ 
R. W. AND CO. 
S. AND D. 
1 
0. 010 
— 1 
0. 025 
.012 
! 026 
+ 
.014 
— 
.027 
2 
.014 
+ 2.. 
.026 
.016 
+ 
! 027 
.018 
+ 
.028 
+ 
3 
.015 
+ 3 
. 027 
.015 
+ 
! 027 
+ 
.015 
+ 
.027 
a Houghton, J. Am. Med. Ass., Chicago, 1898, XXXI, 959.. 
