55 
by the results obtained by all the methods of assay. Such a list is 
found in Table XI. This is prepared from Table X by adding 
together the numbers denoting the relative position of each prepa- 
ration and dividing the sum by the number of assay methods used. 
Naturally the quotients thus found will stand in inverse ratio with 
the strength of the preparation. 
In this table the results obtained by the “ twelve-hour” -method 
on frogs were not used, as only four preparations were assayed 
according to it, so that no true ranking in relation to the results 
obtained by the other methods could be found. 
Table xi. 
Preparation. 
Sum of 
ratings. 
■ Number 
of assays. 
Final 
result. 
Mulford . . 
15 
- 
2.14 
B., W. and Co 
16 
7 
2.28 
N., B. and Co 
25 
7 
3.57 
H. B. and W 
29 
7 
4. 14 
P., D. and Co 
31 
7 
4.43 
Merrell 
40 
5.71 
S. and D 
42 
7 
6.00 
Lloyd Bros 
58 
7 
8.28 
Digitalone No. 3 
34 
4 
8.50 
Digitalone Nos. 1 and 2 
Such a table as this we think, on the whole, represents very fairly 
the relative strengths of the different preparations examined. It 
represents the final conclusion drawn from a very large series of 
experiments, and on that account ma} x be considered fairly accurate. 
There are only four preparations which would appear to require 
special mention. These are the normal tincture of digitalis made by 
William S. Merrell Chemical Company, of Cincinnati; digitalone 
made by Parke, Davis & Co., of Detroit; the specific medicine, 
digitalis made by Lloyd Bros., of Cincinnati, and tincture digitol 
made by H. K. Mulford & Co., of Philadelphia. Two bottles of 
digitol were examined. By the one-hour method on frogs they did 
not show the same strength, one requiring 0.012 c. c. to produce 
systolic stoppage of the heart in one hour and the other 0.016 c. c. 
(Table IX.) This preparation, as mentioned earlier, is 11 assayed, 
tested physiologically” and standardized to contain 0.025 gram 
digitoxin in 100 c. c. 
The purified normal tincture of Merrell is said to be “a stand- 
ardized neutral tincture of prime digitalis leaves freed from the irritat- 
ing fats and oils.” In our tables the dose of this preparation was always 
calculated upon the basis of fluid extract strength, which is not cor- 
rect, as normal tinctures are said to be made from fresh leaves which 
are put into alcohol. Later the alcohol is expressed and by evapo- 
ration 1 kilo of the solution is made equivalent to 1 kilo of leaves. It 
is thus considerably weaker than a fluid extract on account of the 
moisture content of the fresh plant. But even calculated in this 
