151 
amount of total alkaloids. — Geschafts-Bericht von Caeser & Loretz, 
in Halle a. S., 1905, p. 12. 
Caeser and Loretz outline a method of assay for cinchona bark 
which they propose as a titrimetric estimation controlled by a gravi- 
metric separation of the alkaloid from the resulting mixture. — 
Geschafts-Bericht von Caeser & Loretz, in Halle a. S., 1905. 
Gadd, Sydney C., points out that the official (Ph. Brit., IV) 
process requires slight modifications and great attention to details 
to insure satisfactory results. — Pharm. J., Lond., 1905, v. 21, p. 134. 
Overton, Burr M. (Proc. Kentucky Pharm. Ass.), has made a 
comparison of the U. S. P., Prollius’ and Haubensak’s process of 
assay, and prefers the latter because of its simplicity and of the 
results obtained. He also communicates some information relating 
to the cultivation of C. ledgeriana and C. succirubra in J ava. — Abstr. 
Proc. Am. Pharm. Ass., 1905, v. 53, p. 639. 
Robertson, Philip Wilfred, outlines a volumetric method for the 
estimation of cinchona alkaloids by means of their double thiocy- 
anates. — Abstr. Chem. News, Lond., 1905, v. 92, p. 257. 
van Leersum, P., presents a microchemical method for the estima- 
tion of cinchona barks that depends on the solubility of the liberated 
alkaloids in benzol and chloroform. — Pharm. Weekbl., 1905, v. 42, 
p. 432. 
Tschirch, A. (Schweiz., Wchnschr. f. Chem. u. Pharm.), finds that 
in common with cola the reddish coloration of cinchona bark is 
caused by an enzyme that is readily destroyed by w T ater, even at 80° C., 
in from fifteen to thirty minutes, though it is able to withstand dry 
heat for some considerable time. — Pharm. Post., Wien, 1905, v. 38, 
p. 759. 
Zimmerman, Albert, in an illustrated article describes the cultiva- 
tion of cinchona in Java. — Drug. Circ. & Chem. Gaz., N. Y., v. 49, 
p. 422. 
Deistel (Der Tropenpflanzer, v. 9, pp. 578-580) discusses the 
cinchona plantations of Southeast Africa. — Bot, Centralbl., 1905, 
v. 100, p. 239. 
Just’s Botanischer Jahresbericht (for 1905, v. 33, part 3, p. 777) 
contains several additional references bearing on the cultivation of 
cinchona. Tschirch reviews a sketch of the history of cinchona bark 
by Josef Rompel, S. J., who discusses at some length the importance 
of cinchona to the human race, the literature of cinchona, the pseudo- 
literature, and the search for authentic history regarding the intro- 
duction of the bark. — Apoth. Ztg., Berlin, 1905, v.^20, p. 667. 
van der Wielen, P., discusses the history of the cultivation of 
cinchona, and includes a bibliography. — Pharm. Weekbl., 1905, v. 42, 
pp. 137-153, 201-218. 
