152 
cinchonidiisle: sulphas. 
Francis, John M., points out that the following tests may be of 
assistance in the differentiation of cinchonidine, cinchonine, and 
quinine : 
Optical rotation . — Cinchonine and its salts are dextro-gyrate ; quinine and its 
salts are lsevo-gyrate ; cinchonine and its salts are lae vo-gyrate. 
Melting point . — Cinchonine, about 165° C., and cinchonine sulphate, about 
198° C. ; quinine (rendered anhydrous by drying at about 125° C.), about 175° C. ; 
quinine sulphate (dried by exposure over H 2 SO 4 ), about 205° C. ; cinchonidine, 
about 202° C. ; cinchonidine sulphate, about 205° C. 
Solubility in ether. — Cinchonine very insoluble (stated to require from 560 
to 719 parts) ; quinine readily soluble (anhydrous requires 4| parts, crystalline 
from 22 to 30 parts) ; cinchonidine sparingly soluble (about 190 parts). 
Fluorescence . — Dissolve in water strongly acidulated with H 2 SO 4 . Cinchonine 
not more than a faint fluorescence; quinine, pronounced fluorescence; cin- 
chonidine, not more than a faint fluorescence. 
Thalleioquin test (see U. S. P., VIII, under quinine). — Cinchonine, no re- 
action ; quinine, marked reaction ; cinchonidine, marked reaction. — Bull. 
Pharm., Detroit, 1905, v. 19, p. 365. 
CDJHALDEHYDUM. 
Umney and Bennett point out that their experience with cinnamic 
aldehyde, so far, has not been favorable, as it appears to possess a 
suspicion of the odor of benzoic aldehyde, which is not present in the 
natural oil of cassia, and which certainly is a disadvantage. — Pharm. 
J., Lond., 1905, v. 21, p. 146. 
CINNAMOMUM. 
Spaeth, E., discusses some of the characteristics of the several 
varieties of commercial cinnamon, and suggests that a cinnamic alde- 
hyde requirement be provided for. He defines cinnamon as being 
derived from one or more of the three well characterized varieties of 
cinnamon, and not extracted in whole or in part. The addition of 
the wild varieties of cinnamon is not permissible. The amount of 
ethereal oil should not be less than 1 per cent. The ash content of the 
air dry drug should not exceed 5 per cent, and the amount of ash not 
soluble in 10 per cent hydrochloric acid should not exceed 2 per 
cent. — Ztschr. f. Unters. d. Nahr. u. Genussm., 1905, v. 10, p. 33. 
Gadd, H. Wippell, asserts that powdered cinnamon bark should 
not yield more than 6 per cent of ash. — Pharm. J., Bond., 1905, v. 21, 
p. 901. 
Holmes (from Pharm. J., Lond.) describes the bark of Cinna- 
momum pedativum , a “wild cinnamon,” which, he concludes, might 
be of value as a source of safrol and linalooh— Pharm. Zentralh., 
1905, v. 46, p. 689. 
