153 
COCA. 
Francis, John M., believes that for the present the Java coca leaf 
should be interdicted for any other purpose than the manufacture of 
cocaine. He seriously questions the advisability of using the Truxillo 
leaf for the preparation of galenicals, particularly in view of its lesser 
content of cocaine and its possible or probable content of isotropy 1 
cocaine. — Bull. Pharm., Detroit, 1905, v. 19, p. 449. 
Vanderkleed, Charles E., reports 6 assays of coca leaf, varying 
from 0.446 to 0.725, and concludes that the general quality of the drug 
is very good. — Proc. Penna. Pharm. Ass., 1905, p. 55. 
Greshoff, M., discusses the valuation of Java coca, outlines a method 
of assay and publishes the findings which confirm the general observa- 
tion that young leaves contain more than twice the amount of alkaloid 
that is contained in the older ones. — Pharm. Weekbl., 1905, v. 42, pp. 
286-290. 
de Jong, A. W. K., outlines a modification of the Keller method, in 
which the dried and powdered coca leaves are treated with a mixture 
of ammonia and ice cold ether, using hydrochloric acid for the separa- 
tion of the alkaloid. The method is said to separate all of the avail- 
able alkaloids, with the exception of benzoylecgonin. — Chem. Cen- 
tralbl., 1905, v. 76, p. 1198 (from Rec. trav. chim. Pays-Bas, v. 24). 
An editorial in commenting on wine of coca says : 
The introduction of this product can not be commended either on pharma- 
ceutical, medical, or ethical grounds. — Drug Topics, 1905, v. 20, p. 199. 
Lyons, A. B., points out that the strength of wine of coca (64 per 
cent) conflicts with the desirable principle of uniformity in the per- 
centage strength of galenical preparations. — Proc. Am. Pharm. Ass., 
1905, v. 53, p. 257. 
Caldwell, Paul, points out that, fluid extract of coca being quite 
resinous and red wine containing so little alcohol, more added alcohol 
should be used in making the wine of coca. — Drug. Circ. & Chem. 
Gaz., 1905, v. 49, p. 307. 
COCAHSTA. 
Vanderkleed, Charles E., points out that although adulterated 
cocaine is not common, it is . well carefully to examine each lot, not 
only for intentional adulteration, but also for the presence of the 
more poisonous coca bases, cinnamyl cocaine and isotropyl cocaine, 
detected by the permanganate and Maclagan’s test, respectively. — 
Proc. Penna. Pharm. Ass., 1905, p. 54. 
Carlson (Pharm. Zentralh., v. 45, p. 69) asserts that the addition 
of the sulphuric acid to the permanganate test is not necessary, and 
that its omission really makes the test more delicate — Pharm. Prax., 
1905, v. 4, p. 467. 
