154 
Reichard (Pharm. Ztg., v. 49, p. 150) reviews several known 
cocaine reactions and proposes a test with a solution of uranium 
nitrate (1 per cent), to which a few drops of a concentrated solution 
of potassium sulphocyanate have been added. This mixture pro- 
duces, in solutions of cocaine hydrochloride, an intensely yellow pre- 
cipitate. — Pharm. Prax., 1905, v. 4, p. 308. 
Aurelj (Giorn. farm, ehim., v. 53, p. 385) reviews the reactions 
for cocaine and the suggestions that have been made by Schiirges, 
Biel, and Siemssen, and outlines a test for cocaine based on the 
demonstration of the several components. — Pharm. Prax., 1905, v. 
4, p. 308. 
Hoger, Fritz, discusses the substances that are now being used as 
substitutes for cocaine, and points out the chemical relationship that 
exists between them. — Apoth. Ztg., Berlin, 1905, v. 20, p. 886. 
Duffour and Ribaut (from Rep. de Pharm.) find that decomposi- 
tion is likely to occur on heating solutions of cocaine, despite all 
precautions. The most necessary precaution is to avoid glass hav- 
ing an alkaline reaction. — Pharm. Zentralh., 1905, v. 53, p. 929. 
Berry, J. M., reports on experiments made to determine the influ- 
ence of adrenalin chloride on the absorption of cocaine. He con- 
cludes that adrenalin does not protect the body against the toxic dose 
of cocaine, but appears to enhance its toxic action. — Am. J. M. Sc., 
Phila., 1905, v. 130, pp. 893-902. 
Bruardel, P. (from Ann. d’hyg., Paris, 1905, v. 4, pp. 223-255), 
discusses poisoning by cocaine. — Reference from Ind. Med., 1905, 
p. 1052. 
COCAINE HYDUOCHLORIDUM. 
Siedler, P., points out that the Ph. Germ., IV, requires a melting 
point of 183°C. On careful heating cocaine hydrochloride was found 
to melt at 182°, while rapid heating required as high a temperature 
as 190° and even more. — Pharm. Post,, Wien, 1905, v. 38, p. 568. 
Gadd, H. Wippell, commends Maclagan’s (the U. S. P., VIII, 
ammonia) test as being the most satisfactory for the detection of 
other coca alkaloids. — Pharm. J., Lond., 1905, v. 21, p. 902. 
coccus. 
Francis, John M., points out that cochineal is invariably a filled 
drug, as the trade would not accept an article which had not been 
whitened and polished with talc or some similar substance. He has 
examined many samples which yielded more than 6 per cent of ash. — 
Bull. Pharm., Detroit, 1905, v. 19, p. 449. 
Havenhill, L. D., reports a sample of cochineal which contained 
5.8 per cent of moisture and 30.5 per cent of ash. — Proc. Kansas 
Pharm. Ass., 1905, p. 91. 
