155 
Patch, E. L., reports 26 to 46 per cent ash. Kebler, Lyman F., 
reports 39 per cent ash, with tinctorial power one-fifth normal.— 
Proc. Am. Pharm. Ass., 1905, v. 53, p. 183. 
CODEINA. 
Francis, John M., points out that it is essential that codeine should 
be tested for freedom from morphine, and also carefully tested for 
solubility in water. He asserts that some samples of codeine phos- 
phate are not nearly so soluble in water as they should be for “ hypo- 
dermics.” — Bull. Pharm., Detroit, 1905, v. 19, p. 449. 
Caspari, Charles E. (Apoth. Ztg., v. 19, p. 874, and Proc. Am. 
Pharm. Ass., v. 52, p. 386), outlines a method for the determination 
of codeine in opium. — Year Book Pharm., Lond., 1905, p. 65. 
Dekker, J., discusses the solubility of codeine in water, and sug- 
gests that the Ph. Ydl. requirement, 1-80, is too high. He believes that 
1-117 to 118 of cold water (15° C.) is more nearly correct. — Pharm. 
Weekbl., 1905, v. 42, pp. 188-189. 
Halle, Walter L., in discussing the relationship of codeine to mor- 
phine, outlines the history of the former, and gives some additional 
data and references relating to its production by the methylating of 
morphine. — Chem. Ztg. Cothen, 1905, v. 29, p. 1264. 
Eodionow, N. D., points out that the unequal behavior of codeine 
and dionin to ammonia and to Wagner’s reagent offers a satisfactory 
method for differentiating between these two substances. — Pharm. 
Ztg. Berlin, 1905, v. 50, p. 561 (from Farmazeft, 1905, p. 102). 
Pelz (Deutsch. Med. Woch., Fo. 22, p. 864) reports a case of codeine 
mania which, the author believes, controverts the frequently made 
assertion that there is no such thing as a codeine habit. — Biochem. 
Centralbl., 1905, v. 4, p. 169. 
COLCHICI CORMTJS. 
Beringer, George M., in speaking of the wine of colchicum root, 
says : 
The reason for its dismissal is not understood. It is extensively used. — Proc. 
Am. Pharm. Ass., 1905, v. 53, p. 415. 
Francis, John M., points out that — 
In view of the disparity in alkaloidal content, we question the advisability of 
retaining the colchicum root. Assays of seventeen consignments of colchicum 
root averaged 0.35 per cent of colchicine ; the highest assayed 0.45 per cent, and 
the lowest 0.20 per cent, 4 of the 17 consignments assaying below the U. S. P., 
VIII, standard of 0.35 per cent. — Bull. Pharm., Detroit, 1905, v. 19, p. 450. 
Yanderkleed, Charles E., reports 9 assays of colchicum root, vary- 
ing from 0.324 to 0.50 per cent of colchicine. The general quality of 
this drug he believes to be good. — Proc. Penna. Pharm. Ass., 1905, 
p. 56. 
