157 
in flexible collodion, and recommends that this substance be dis- 
solved and filtered before being added. — Abstr. in Proc. Am. Pharm. 
Ass., 1905, v. 53, p. 523. 
COLOCYNTH, 
Lyons, A. B., points out that the U. S. P., VIII, describes the 
peeled fruit, but that the dose given is that of the drug deprived of 
seeds. — Proc. Am. Pharm. Ass., 1905, v. 53, p. 261. 
Francis, John M., notes that there are few drugs which offer greater 
temptations to fraud than this. The U. S. P. requires that from 
60 to 75 per cent of the weight of the drug must be sacrificed by dis- 
carding the seed and the rind. Besides this loss, there must be added 
the labor involved, and it naturally follows that there is a strong 
temptation to grind all together and extract in the usual way. — Bull. 
Pharm., Detroit, 1905, v. 19, p. 450. 
Lloyd, John Uri, points out that colocynth may be true to name, 
of prime fresh quality, and yet not in a condition to be used in 
medicine. The loss in the required manipulation is so great that 
some persons can not bear to meet the issue. — Pharm. Review, 1905, 
v. 23, p. 300. 
Howard, Clarence, in recording twenty years’ experience with colo- 
cynthis, says: 
Neuralgic attacks in any part of the body, following the wounding of pride, 
anger, a display of ungovernable temper, are quickly relieved by colocynthis. — 
Hahneman. Month., Phila., 1905, v. 40, p. 791. 
CONIUM. 
Vanderkleed, Charles E., reports 3 assays of conium seed varying 
from 0.40 to 0.76 per cent of coniine. — Proc. Penna. Pharm. Ass., 
1905, p. 56. 
Rusby, H. H., believes that conium preparations are considered 
to be unreliable by physicians largely because the quality of the drug 
is poor. — Merck’s Rep., 1ST. Y., 1905, v. 14, p. 212. 
Naylor, W. A. H., points out that, from the experiments of Find- 
lay, coniine may be regarded as the active principle of conium, the 
other alkaloids not existing in large enough proportions to greatly 
modify its action. — Pharm. J., Lond., 1905, v. 21, p. 126. 
Maben, Thomas, believes that standards should be based on the 
commercially obtainable drug of fair quality, and points out that 
the inferior quality of commercial conium may be due to the fact 
that it is much easier to harvest the ripe than the unripe fruit. — 
Ibid ., p. 140. 
v. Braun, J., reports some experiments made to separate the several 
alkaloidal bases present in conium. — Ber. d. deutsch. chem. Gesellsch., 
1905, v. 38, pp. 3108-3112. 
