165 
oil with hypophosphites, and advises against the making up of any 
considerable amount of stock until the pharmacist has proven the 
process and gained the necessary skill through actual trial. — Bull. 
Pharm., Detroit, 1905, v. 19, p. 452. 
EPINEPHRINA. 
Aldrich, Thos. B., reviews the history of the active principle of 
the suprarenal glands from Addison (1855) to Takamine (1901) and 
discusses the empirical and structural formulas. He also presents 
an extensive bibliography bearing more directly on this particular 
phase of the work. — J. Am. Chem. Soc., 1905, v. 27, pp. 1074-1091. 
Abel and Taveau discuss the differences that occur in the nitrogen 
content of epinephrin prepared at different times, and the changes 
produced by repeated solution and precipitation. They point out 
that the generally accepted constitutional formula for epinephrin 
does not correspond to all of the facts brought out by a study of the 
decomposition products, and should not be accepted without further 
investigation. — J. Biol. Chem., N. Y., 1905, v. 1, pp. 1-32. 
Bertrand, Gabriel (Bull. Soc. Chim., v. 31, pp. 1289-1292), records 
the physical characteristics of adrenalin. — Analyst, London, 1905, 
v. 30, p. 22. 
Abelous, Soulie, and Toujan (Compt.-rend. soc. biol., v. 58, pp. 
301-302, 533-534, 574L576) discuss a colorimetric determination of 
adrenalin by means of iodine, the formation of adrenalin by the 
adrenal gland, and the origin of adrenalin. — Abstr. in Jahresb. (for 
1905), ii d. Tier-Chemie, 1906, v. 35, p. 564. 
Kwisda, A., discusses the reports on the blood pressure raising 
principle of the adrenal gland, published during the past few months 
by French and German investigators. — Schweiz, Wchnschr. f. Chem. 
u. Pharm., 1905, v. 43, p. 351. 
Friedmann, E., has attempted to solve the question regarding the 
constitution of adrenalin by synthesis, from the substance described 
by Fiirth as tribenzolsulfo adrenalin. Friedmann agrees with Jowett 
as regards the structural formula for adrenalin. — Beitr. z. chem. 
Phys. u. Path., 1905, v. 6, p. 93. 
Barger and Jowett present a discussion of the synthesis of sub- 
stances allied to epinephrin, and present experimental data relating 
to the production of these substances. — J. Chem. Soc., Lond., 1905, 
v. 97, part 2, pp. 967-974. 
Dakin, Henry Drysdale, discusses the synthesis of substances allied 
to adrenalin and gives a detailed account of a compound having the 
constitution generally accepted for adrenalin. — Biochem. Centralbl., 
1905-6, p. 567. See also Proc. Roy. Soc., Lond., v. 76, pp. 491-497 ; 
and for a discussion of the physiological activity of substances indi- 
rectly related to adrenalin; Ibid., pp. 498-503. 
