187 
Dohme, A. R. L., asserts that the quality of hydrastis improved 
steadily from 1899 to 1902 and then gradually began decreasing 
again. He also asserts that the spring root is better than the fall 
root, and gives the average alkaloid content for the years 1899 to 1905, 
inclusive. — Apothecary, Boston, 1905, v. 17, p. 942. 
Hartwich and Hellstrom (Apoth. Ztg.) give a key according to 
which, they assert, it is quite possible to recognize the several roots 
that have been employed as adulterants of hydrastis. — Pharm. Prax., 
1905, v. 4, p. 229. 
The committee on adulterations found a sample of extract of 
hydrastis which contained, as a diluent and absorbent, infusorial or 
siliceous earth. — Proc. Michigan Pharm. Ass., 1905, p. 79. 
Caeser and Loretz suggest a method for the assay of hydrastis in 
which they recommend a mixture of 100 gms. of ether and 20 gms. of 
benzine as a solvent. — Geschafts-Ber. v. Caeser & Loretz, in Halle 
a. S. 5 1905, p. 96. 
Maben, Thomas, believes that the allowance for a loss of 20 per cent 
of the alkaloid in the manufacture of the fluid extract appears to be 
excessive. — Pharm J., Lond., 1905, v. 21, p. 141. 
Koning, J. (from Pharm. Weekbl., 1905, No. 42), examined 8 
different samples of extracts of hydrastis and found but 2 which 
complied with the requirements of Ph. Germ., IY, for alkaloid. — 
Pharm. Ztg., Berlin, 1905, v. 50, p. 919. 
Newton, C. H. W., gives some historical notes and several formulas 
for preparations of hydrastis. — Proc. Connecticut Pharm. Ass., 1905, 
pp. 39^12. 
Hammer, J. W., discusses the formula for fluid extract of hydrastis, 
included in Ph. Svec., VIII, and the extract content. — Svensk. Farm. 
Tidskr., 1905., v. 9, pp. 65-67. 
Crance, A. J., points out that — 
The specific affinity of hydrastis in disease expression is that of a mucous 
membrane tonic. * * * The specific indications are an increased secretion 
from mucous surfaces with atony, as evidenced by impaired circulation and 
innervation. — Eclectic M. J., 1905, v. 65, pp. 203-205. 
See also Snyder, George. — Ibid., p. 376. 
An abstract asserts that hydrastis, while it is quite rapidly elimi- 
nated from the body if the kidneys are in a healthy condition, may 
accumulate in the system in chronic interstitial nephritis and produce 
a series of symptoms, among them headache, vertigo, blurred vision, 
nausea, constipation, and convulsions. — Hahneman. Month., Phila., 
1905, v. 40, p. 612. 
HYOSCIN^: HYDROBROMIDUM. 
Kobert, R., points out that the name “ hyoscin ” originated with 
Ladenburg, who applied it to a substance having a chemical formula 
