FURTHER STUDIES UPON THE PHENOMENON 
of anaphylaxis: 
By Milton J. Rosenau, 
Surgeon , Director Hygienic Laboratory , U. S . Public Health and Marine- Hospital 
Service , 
and 
John F. Anderson, 
Passed Assistant Surgeon, Assistant Director Hygienic Laboratory, U. S. Public Health 
and Marine-Hospital Service. 
Studies upon anaphylaxis, both in this country and abroad, indi- 
cate that the phenomenon has an important bearing upon certain 
fundamental problems in medicine. 
A satisfactory explanation of the intimate nature of anaphylaxis 
would doubtless give us a much better understanding of a large class 
of diseases. The close relationship between anaphylaxis and im- 
munity is evident. Advances in our knowledge of the former will 
surely lead to practical progress in the latter. 
There appears to be much similarity between anaphylaxis and the 
processes that take place in tuberculosis. Diseases like hay fever 
find their explanation in a specific hypersusceptibility. The serum 
disease, following the introduction of alien proteins and the hyper- 
susceptibility that some persons display to certain proteins when 
ingested, are frequent clinical instances of anaphylaxis, the mani- 
festations of which are multiple and various. 
We shall doubtless know more about the endotoxins, the period of 
incubation of disease, protein metabolism, and other obscure prob- 
lems in pathology, when we know more about the phenomenon of 
anaphylaxis. These and other practical bearings of the subject 
have been dwelt upon by us in a recent lecture before the Harvey 
Society . 6 
a Manuscript submitted for publication April 5, 1909. 
b Arch. Internal Med., April, 1909 (in press). 
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