12 
Table No. 5. — Paraldehyde — Continued. 
G. P. No. 
G. P. 
weight. 
Injection. 
Result. 
Control 
Grams. 
385 
1 1 
0. 9 c. c. paraldehyde by the mouth, narcosis complete 1 . 
Recovered. 
MAGNESIUM SULPHATE. 
The experiments of Meltzer with the use of magnesium sulphate as 
an anaesthetic prompted us to make some experiments with this 
substance for the prevention or modification of anaphylaxis. These 
experiments varied in several particulars. 
In one series (Table No. 6) sensitive guinea pigs were given 
sufficient magnesium sulphate subcutaneous^ to render them com- 
pletely anaesthetic, and then they were given an injection of horse 
serum containing sufficient calcium chloride in solution to counteract 
the effect of the magnesium sulphate. 
In another series the animals were given the same treatment, 
except that no calcium chloride was included in the serum. 
Another series was given the magnesium sulphate; then, when the 
narcosis was complete, they were given calcium chloride subcuta- 
neously and within one or two minutes given the injection of serum. 
Others were given magnesium sulphate, then the serum and, 
before symptoms appeared, the calcium chloride. 
It will be seen from the results in the tables that none of these 
procedures seem to exert any favorable influence upon the final result. 
Table No. 6. — Magnesium sulphate, then calcium chloride dissolved in horse serum. 
G. P. No. 
G. P. 
weight. 
First injection. 
Inter- 
val in 
days. 
Second injection. 
Result. 
11060 
Grams. 
475 
0.23 c. c. toxine 7+1/300 
86 
0.5 gm. in a 25 per cent so- 
Dead in 27 minutes. 
11061 
475 
c. c. antitoxic horse se- 
rum (LB 1254). 
0.23 c. c. toxine 7+1/400 
86 
lution of MgS 04 , sub- 
cutaneously. 43 min- 
utes later, narcosis com- 
plete,, 6 c. c. solution of 
0.1 gm. CaCh+normal 
horse serum, subcuta- 
neously. 
0.5 gm. in a 25 per cent so- 
Dead in 14 minutes. 
c. c. antitoxic horse se- 
rum (LB 1254). 
lution of MgS04, subcu- 
taneously. 25 minutes 
later, narcosis complete, 
6 c. c. solution of 0.1 gm. 
CaCh+normal horse se- 
rum, subcutaneously. 
