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meal. The other 5 persons became ill at different times ; the last one 
about ten days after eating the meal that apparently poisoned the 
guest. A calf using the same milk sickened with “ trembles ” soon 
after the earliest cases in the family. The cow accused of imparting 
the disease developed “ trembles ” and died. The cow showed no 
symptoms until milking was neglected on account of illness in the 
family. It was believed that this cow had been on milk-sick land 
about two weeks prior to the outbreak. This outbreak seems to have 
been a typical one, the sickening of the cow only after she was no 
longer milked, the sickening of the calf at about the same time that 
some of the persons were attacked, the onset of the illness at a vary- 
ing period after the use of the suspected milk and butter, finally, the 
exemption of the only person who did not partake of the milk or 
butter, all agree with the older descriptions. As trembles and milk 
sickness are both so rare at present, an occurrence like this points 
strongly to a most intimate relation between them. 
The few recorded post-mortem examinations throw little light upon 
the nature of the disease. Horne (1844) , who examined three human 
cases, found inflamed patches in the small intestine. The mesenteric 
glands were red and greatly enlarged. 
In animals, Graff found the brain “ suffused with a large quantity 
of blood, which, from the amount contained within the cranium, must 
have made great pressure on every part.” In one human case he 
found softening of the brain and evidence of meningitis. Graff tells 
us that this autopsy was conducted “ by stealth at night in the open 
air, and by the light of a single candle.” 
Barbee (1840) found the colon in man “ contracted to the size of a 
common candle.” The mucous membrane of the stomach was red and 
thickened in spots; the remainder presented a pale and softened ap- 
pearance. The peritoneal coat of the small intestines was inflamed. 
Jordan and Harris made a number of post-mortem examinations 
on the lower animals. They noted the odor of acetone when the body 
cavities were opened. This is interesting in view of the statement of 
most of the old writers that there is a peculiar and characteristic odor 
of the breath in milk sickness.. The other findings in cattle were, 
briefly, as follows: 
Small amounts of fluid in pleural and pericardial sacs, numerous 
ecchymoses beneath the visceral pericardium. The heart muscle was 
paler than normal and when sections were examined general cloudy 
swelling was found. A general injection of the vessels or the small 
intestine was present. The liver was always enlarged, purple red, 
sometimes with streaks of yellowish. Microscopical examination 
showed cloudy swelling and fatty degeneration of the organ. The 
gall bladder was usually full of dark-green bile. The liver tissue 
was very friable, occasionally yellowish red, and gave the appearance 
