87 
A number of writers, particularly Giles. Sandwitli, and others, 
agree that small doses of thymol are valueless, but Sandwith is of the 
opinion that 4 grams in 24 hours are as eflicacious as d grams, and the 
former dose is certainly less dangerous. 
Worms may be found in the stools as early as eight hours after the 
first dose of thymol. In 50 cases Sandwith counted 1.2ol worms in 
stools passed within eight hours after the first dose and 444 worms 
within the next sixteen hours. From his context, however, it is clear 
that brandy was given to these patients (see below), hence the thymol 
was dissolved more rapidly. Giles reports that he s(ddom found any 
worms until twelve hours after the first dose of thymol. ••Occasion- 
ally patients vomited after swallowing thymol, but as a rule they 
retained it perfectly,'' and ••they used to ask for an extra dose of it 
while convalescing." 
Sandwith goes on to sa}" that •‘lai’ge doses of thymol havt‘ a poison- 
ous etfect on the system, not unlike those i)roduced by cai-bolic acid. 
The temperature is lowered one or even two degrees centrigrad(‘, and 
both pulse and respiration are slowed. The ])atient remains fora few 
hours collapsed, giddy, and faint, and has to b(‘ kept lying down, but 
at sunset he is quite well again and asking for food." 11(‘ gives the 
following as a typical case: 
January 14, 1892 . — 6 a. m., temperature 37.5°, jmlse SO, respiration 19; j»atient in 
his iLsual state and was gi^'^n 2 grains of thymol. 7 a. m., temperature 37°, pul.'Hi 
80, respiration 19; says he has slight nausea, gi<ldiness, and colicky {tains in the 
epigastrium. 8 a. m., 2 grams more of thymol given. 9 a. m., tem]K*rature :15.5°, 
{Hilse 70, res{uration 17; great giddiness, can not stand or walk; very sh*e{>y, and 
talks like a drunken or very .slee{)y man. 12 a. m., sym{)toms much thesiime; sweat- 
ing while aslee]). 2 j). m., tem{)erature 37.5°, pulse 75, res{tiration IS; a|>parently 
quite well again. Says lie does not mind the thymol, exce{>t that it makes him lose 
consciousness. ’ ’ 
Some author.s advise the use of alcohol with tliymol. othm-s warn 
against such use. Sandwith. in nd’erring to this subjiud, .says: 
“Warned b}^ the detith of ;it least one of my patitMits immediatidy 
after digesting the thvmol, I have always administered to feebh‘ ni«*n 
25 grams of brandy with eacli 2 grams of thymol, with the happiest 
results.’' 
Authors who warn against the use of alcoholics during treatment do 
so on the ground that thymol is .solubh* part for part in alcohol, hence 
will more ([uickly be ab.sorbed by tin* system. ^\ ith one of iny assist- 
ants (see Stiles tSi; Pfeiuhu*. lH02a), in the Bureau of Animal Indu>'trv, 
I treated a number of dogs with thvmol in vai'ious forms. \\ e gave 
do.ses varying from 10 to loo grains ((t0>4s to 0.4S gmms) t<» dogs 
weighing from S to 35 i)ounds. In alcoholic .M)lution, 2>o grains (1.04 
grams) cau.sed convulsions in a dog weighing 15 jxmnds, and .seven* 
convulsions in one weighing 14 pounds; on tin* otln*r hand, an S-pound, 
old dog sutiered no ill effects aft(*r 30 gi^jiins in alcohol, and a 3;)-pound 
