88 
dog took 75 grains (d.86 grams) in alcohol without deleterious effect. 
In tablet form. Avithout oil. a single dose of 100 grains (6,18 grams) 
killed a dog of 15 pounds in four days; a dose of 50 grains caused a 
l:2-pound dog to attempt to A*omit: a dose of 75 grains A\'as Avithout 
appreciable effect in a dog of 35 pounds : 30 grains Acere AA-ithout effect 
on a dog of 8 pounds: daily doses of 20 grains each caused a slig'ht 
diarrhea after six days in a dog of 15 pounds: the same dose caused a 
17-pound dog to be cptite sick on the sixteenth day. In tablet form. 
Avith castor oil. 30 grains caused a 12-pound dog to attempt to vomit, 
Avhile doses of 10 and 20 grains Avere negative on dogs Aveighing 12 to 
15 pounds. In poAA-dered form. AA-ithout oil. 20 grains caused a 12- 
pound dog to attempt to A'omit. Avhile doses of 10 and 20 grains respec- 
tively AA*ere negative in dogs of 12 and 15 pounds: 10 grains caused no 
ill effects in a dog of 8 pounds, and a dose of 80 grains AA-as Avithout 
effect on a dog of 35 pounds. In poAA*dered form. Avith castor oil. 20 
grains caused slight conA'ulsions in a dog Aveighing 15 pounds, but 
doses of 10 and 20 grains Avere negative on dogs of the same AA'eight. 
nine foxes to Avhich AA*e gave 3 grains in alcohol became C[uite sick. 
Theobald states that a dose of 3 grains has produced partial prostra- 
tion in a bull-terrier, but he does not glA'e the Aveio-ht of the dog. 
According to SandAvith. the contra-indications for thymol are ** excess- 
iA'e debility. A’ery Ioav temperature, age above 60. and adA’anced diseases 
of the heart or any other organ. Boys take it very AA-ell in half quan- 
tities.” 
SandAvith states (1891. p. 17). that of 8 fatal cases treated Acith 
thymol 2 died, he thinks, in consequence of the thymol, eleven and 
forty-eight hours, respectively, after taking the dose: both of these 
men had previously had thymol AArithout bad effect, but they Avere 
both in a miserable state of exhaustion and debility. He does not 
think that thvmol accelerated the deaths of anv of the remaining 6 
cases. AA'hich occurred fi\*e, six. nine, thirteen, fifteen, and nineteen 
days. respectHely. after the last dose of thymol. Three of these cases 
AA-ere over 65 years of age. 
While my experience AA^ith thymol in man is very limited. I must 
confess that from my experiments upon animals. I am afraid of the 
use of alcoholics per os during treatment, and in the case of Aveak 
patients I should be more inclined to use a stimulant hypodermically 
than run the risk of dissolA*ing the thymol too rapidly or in too great 
quantity at one time. Furthermore, it is at least doubtful Avhether 
our American hookAcorm aaBI be so difficult to expel as is the Old 
World species, because of the absence of the ventral hooks (cf.' figs. 5 
and 10) in Uncinaria aniericcma. 
In the case of “excessive debility" and other conditions AA'hich 
SandAvith designates as contra-indications for thymol, it is not clear 
Avhat drug SandAvith Avould use. for he states (1891, p. 20) that “for 
