24 
TRYPANOSOMIASIS IN MAN. 
Trypanosomiasis as a disease of man has not yet become acclimatized 
in the United States. At least no cases have been reported in this 
country. There have appeared in the foreign journals within the 
IDast year, however, eleven authentic instances of infection with 
trypanosomes. 
A case of trypanosomiasis in a European, by Dutton (11) and Forde 
(12). — The patient was a European, 42 years of age, master of a gov- 
ernment steamer on the Gambia River, in TT est Africa. 
On 3Iay 10, 1901, the patient was admitted into the hospital at 
Bathurst, W est Africa, suffering from what was regarded as malarial 
fever. Examination of his blood did not show malarial parasites, but 
there were seen extremely active bodies which were regarded as filaria. 
Three weeks later the j)atient was invalided to Liverpool, but returned 
in December, 1901, to Bathurst, where Dr. Dutton, of the Liverj)Ool 
School of Trox)ical Medicine, examined the patient’s blood and found 
the same parasite which F orde had probably seen seven months pre- 
viously and which he at once recognized as a trypanosome. 
The symptoms were an irregularly intermittent fever, a very marked 
erythema multiforme of the trunk and limbs, an oedematous condition 
of the face beneath the eves and of the ankles, an acceleration of 
respiration and pulse rates, debility and loss of flesh, and enlarged 
spleen. The symptoms persisted throughout the eight months during 
which he was under observation and showed no reaction to treatment 
further than a slight abeyance under Fowler's solution. 
Dutton found, while making examinations of fresh blood during the 
month of December, 1901, an average of one and one-half trypano- 
somes to each cover slip t>reparatiou. One reparation showed as 
many as 15 parasites. This case continued in its chronic course until 
the last week of life, during which week the disease assumed an 
acute type and the patient died January 1, 1903. 
Dutton suggests the name Trypanosoma gamhiense in case that 
further study shows it to be a new species. 
A second case of trypanosomiasis in a European, by Manson (13). — 
The patient was the wife of a missionary on the Tapper Kongo, where 
she had lived for a year. On account of sickness she returned to 
London. 
Dr. Manson, of the London School of Tropical Medicine, recogniz- 
ing the same group of symptoms which the patient of Dutton and 
Forde presented, made systematic, careful examinations of her blood 
daily for two weeks. During the two weeks no trypanosomes were 
found, but at the end of this time the parasites were readily -seen in 
the i)erij)heral circulation. 
Trypanosomes in the Nood of a IVest Africa native, by Dutton 
(11). — Three trypanosomes were found in a single smear from the 
