April 27 . at 11 a. m.. bv Drs. Bryce and Wilson. Spots were numer- 
ous. large, and covering entire body, were rosy in appearance except 
on dependent portions, where they were somewhat darker in color. 
Temperature 101. pulse 101. respiration 26. Fresh blood showed a few 
red cells containing oro-anisms. Count showed — 
lied blood corpuscles 4. 576, 000 
White blood corpuscles 7, 300 
Hemoglobin - percent.. 70 
At Dr. Wilson's suggestion, the patient's room was darkened, with 
apparent o*ood results in allaying restlessness. 
Patient examined again April 29 by Drs. Bryce. Johnson, and Wil- 
son. Examinations of fresh blood showed many red blood cells con- 
taining oro-anisms. Count showed — 
Eed blood corpuscles 3, S20, 000 
Leucoc>*tes S. 000 
Hemoglobin j)er c-ent . . 50 
Patient exammed again May 2 by Drs. Bryce. Anderson, and Wil- 
son. Patient very weak: condition otherwise much as before. Spots 
somewhat darker on dependent portions, but more rosy over remainder 
of body. Temperatime 102.5. pulse 120. respiration 2S. Patient had 
had only strychnine for the last twenty-four hours. Given subcuta- 
neous injection of quinine hydrochlorate 2" grains at time of visit. 
Examination of fresh blood showed a few organisms in red cells. 
Count gave — 
Eei blood corpuscles 3. 920, 000 
Leucocytes S, 500 
Hemoglobin per cent . . 60 
(Specimen taken from same point as that of April 27.) 
Patient passed into a state of semiconsciousness, gradually increas- 
ing to total unconsciousness, which gradually passed away, having 
lasted seventy-two hours. 
Pulse about 120. tempemture ran between 102.5 in the morning to 
103.5 in the afternoon until May 9, then it dropped to subnormal. 
The spots remained dark until about the iLth. when they became much 
lighter, gradually disappearing, first from the extremities and back. 
Pecovered. 
Treatment; Bowels kept open with calomel. Quinine sulphate 2. 6 
grams by mouth every twenty-four hours, and quinine hydrochlorate 
in gradually increasing doses up to 3. 3 grams every twenty-four hours 
hypodermically until improvement began, then gradually decreased. 
Patient was frequently given hot sponge baths, which allayed the 
restlessness and lessened the congestion of the skin, causing spots to 
change from dark red to rosv red. 
