28 
April 27,* at 11 a. m., by Drs. Biyceand Wilson. Spots were numer- 
ous, large, and covering entire body, were rosy in appearance except 
on dependent portions, where they were somewhat darker in color. 
Temperature 101, pulse 101, respiration 26. Fresh blood showed a few 
red cells containing organisms. Count showed — 
Eed blood corpuscles 4, 576, 000 
White blood corpuscles 7, 300 
Hemoglobin per cent . . 70 
At Dr. Wilson’s suggestion, the patient’s room was darkened, with 
apparent good results in allaying restlessness. 
Patient examined again April 29 by Drs. Bryce, Johnson, and Wil- 
son. Examinations of fresh blood showed manv red blood cells con- 
taining organisms. Count showed — 
Red blood corpuscles 3, 820, 000 
Leucocytes 8, 000 
Hemoglobin per cent. . 50 
Patient examined again May 2 by Drs. Bryce, Anderson, and Wil- 
son. Patient very weak; condition otherwise much as before. Spots 
somewhat darker on dependent portions, but more rosy over remainder 
of body. Temperature 102.5, pulse 120, respiration 28. Patient had 
had onlv strychnine for the last twent 3 "-four hours. Given sultcuta- 
neous injection of quinine h^Mrochlorate 20 grains at time of visit. 
Examination of fresh blood showed a few organisms in red cells. 
Count gave — 
Red blood corpuscles 3, 920, 000 
Leucocytes 8, 500 
Hemoglobin ])er cent . . 60 
(Specimen taken from same point as that of April 27.) 
Patient passed into a state of semiconsciousness, gradualA increas- 
ing to total unconsciousness, which gradually passed awav, having 
lasted seventy-two hours. 
Pulse about 120, temperature ran between 102.5 in the morning to 
103.5 in the afternoon until Mav 9, then it dropped to subnormal. 
The spots remained dark until about the 11th, when they^ became much 
lighter, gradualh^ disappearing, hrst from the extremities and back. 
Recovered. 
Treatment: Bowels kept open with calomel. Quinine sulphate 2. 6 
grams b}" mouth ererv twenty-four hours, and quinine lyxlrochlorate 
in graduall}" increasing doses up to 3. 3 grams every twentv-four hours 
h^^podermicallv until improvement began, then graduall}^ decreased. 
Patient was frequentlv given hot sponge baths, which allayed the 
restlessness and lessened the congestion of the skin, causing spots to 
change from dark red to rosv red. 
