CONTENTS. 
Page. 
Summary 7 
Introduction 10 
Acknowledgments 10 
Historical review of literature 12 
Definition 14 
Historical reAuew of the disease 15 
Xames of the disease 16 
Historical review of investigations 16 
Specific cause of “spotted fever” 17 
Genus Piroplasma 18 
Species Piroplasma hominis 19 
Method of infection 20 
Tick theory 20 
The burrowing squirrel or gopher {Citellus columhianus) as possible source of 
“spotted fever” 24 
Comparison of “spotted fever” with piroplasmatic diseases in animals 25 
Geographic distribution 25 
Number of cases 29 
Locality of infection 30 
Seasonal distribution 32 
Age and sex of patients 36 
Occupation of patient 38 
Types of cases 39 
Symptomatology 39 
Previous condition of patient • 39 
Period of incubation 40 
Onset 41 
Duration 42 
Epidemic character 43 
Is “ spotted fever ” contagious? 44 
Position in bed 45 
Odor 45 
Skin.. 45 
General condition 45 
Spots: Location; Time of appearance; Duration; Character; Patho- 
logical findings; Comparison 45 
Desquamation 49 
Jaundice 50 
Cyanosis 50 
Gangrene 50 
Hyperesthesia 51 
Fat 52 
( 3 ) 
