34 
with antitoxin), and lack of direct proof of their existence gave 
Arrhenius and Madsen’s contention that the toxones were only the 
toxin which was being slowly freed from the antitoxin-toxine com- 
bination a certain degree of plausibility/'^ 
Calcar was also able to show that the toxones have a greater molecular 
volume than the toxins^ but a smaller molecular volume than the pro- 
teids. 
It therefore seems plain, as Ehrlich states, that his views furnish a 
far better explanation than those of Arrhenius of numerous facts in 
the domain of toxines, such as the process of spontaneous enfeeble- 
ment of toxins^ their passage into a state of stability, the reduction of 
the toxone zone, and the capacity of completely neutralized poisons to 
produce antitoxin (Park) b}" means of von Dungern’s epitoxonoids. 
«Reid Hunt in Gould’s Amer. Yearbook of Med. and Surg., 1905, p. 619. 
