so 
ized manufacturers only after it has been tested by the Koniglich 
preussische Institut fiir experinientelle Therapie zii Frankfurt a. M. 
These tests include the strength of the serum in immunity units 
(Immunisirungseinheiten=I. E.). the freedom from bacteria, and the 
percentages of substances (phenol or trikresol). ’^hich have been 
added as preservatives. 
It is offered for sale in both the liquid and solid forms. 
Liquid and solid antidiphtheric serum are purveyed only in bottles 
which are officially sealed. Upon the label is stated the place of manu- 
facture. the antitoxic value of one cubic centimeter, and the total con- 
tents of the bottle: also the control number and the date on which the 
official control was exercised. These bottles are placed in light-proof 
packages containing the same label: the lead seals show an eagle or a 
lion on the obverse and the total number of immunity units (I. E.) 
contained in the bottle on the reverse. 
The liquid antidiphtheric serum is a yellow, clear Iluid having at 
most a very slight precipitate: it has the odor of the preservative used. 
It is put up in bottles of various form and color, the contents of which 
contain from 100 to 3.000 I. E. The bottles most frequently used are 
those containing: 
No. 0= i>00 I. E. 
No. 1= 000 I. E. (or 500 1. E.) 
No. Il=l.(>0u I. E. 
No. 111=1.500 I. E. 
Antidiphtheric serum which contains more than 3t'0 I. E. in 1 c. c. 
is considered a high grade serum. 
The solid antidiphtheric serum is a dried serum of high grade, and 
contains at least 5.00O I. E. in 1 gram. It contains no antiseptic or 
other added substance. It appears as a yellowish-white powder, solu- 
ble in teu parts of water, giving a solution which, in color and appear- 
ance. resembles the corresponding liquid antidiphtheric serum. 
Single doses of from 25u to l.OoO I. E.. and containing 2 to 6 c. c.. 
are placed in white glass-stoppered bottles. The solution should be 
made with sterile water in the original bottle, using 1 c. c. for each 
250 I. E.. and should be prepared fresh each time. The solution 
should be clear except for little albuminous particles, and should be 
used from the original bottle. 
Serum with a marked permanent cloudiness or an abundant precipi- 
tate is not allowed to be dispensed by the apothecaries: also serums 
with certain control numbers which have been recalled. 
TO BE KEPT IX A COOL PI.ACE AXD PROTECTED FROM THE LIGHT. 
