17 
Excreted in the urine as auiidoplienol or amidophenetol, which gives 
a red color with ferric chloride; also causes appearance of a reducing 
substance. 
Similar Compounds.— This is the representative of a yevj large num- 
ber of similar compounds known as the phenetidin series. These are 
derived from para-amidophenol 
drogen atom of the hydroxjT group and one or both of the h 3 ^drogen 
atoms of the amido (NHg) group by alkyl or acid radicals. Thus, lac- 
tophenin is formed when the lact}^ group (COCH(OH)CH 3 ) is intro- 
duced into para-phenetidin instead of the acetyl (CH3CO) group: 
OC H 
. Sedating apolysin^ citropJien^ Itryofin^ 
malahin^ salophen, saliphen^ phenocoll^ salocoU^ etc., are similar com- 
pounds. The ph}"siological action of all these substances is funda- 
mentall}^ the same. These compounds, as well as acetphenetidin itself, 
are contained in man}" migraine and headache powders. Chinopheiiin 
and e\pyrlne are also phenetidin compounds. 
by replacing the hy- 
ACinUM CAMPHOEICUM. 
Camphoric Acid. 
CsH,,< 
COOH 
COOH 
‘‘A dibasic organic acid obtained by the oxidation of camphor.” 
Official under same name in the German Pharmacopoeia. 
Of the various camphoric acids known, only the dextro-rotatory is 
official. It is prepared by oxidizing camphor with nitric acid. 
Character. — Colorless, odorless crystalline plates, or a crystalline 
powder having an acid, bitter taste. Melting point, 187° C. It forms 
easily soluble salts v/ith the alkalies. 
Solubility. — Difficultly soluble in cold water (1:125), more readily in 
boiling water (1:10); readily soluble in alcohol; soluble in fatty oils 
(1:50). 
Purity. — Should not have the odor of camphor; tested by the IT. S. 
Pharmacopoeia method should be free from nitric acid. 
Action. — The general symptoms produced by camphoric acid are 
similar to those Caused by camphor, but the latter is much more 
powerful. Used as an antihydrotic in doses of 1 to 2 Gm. and (in 
solution) as a local astringent in the nose, throat, and bladder. As it is 
but slightly soluble in water, it has been recommended in making solu- 
tions to add 11 per cent of alcohol for each per cent of camphoric acid. 
Dose. — “Average dose: 1 Gm. (15 grains).” (U. S. P.) 
Guakamphol is a combination of Guaiacol and Camphoric Acid. 
« The name sedatin has also been used as a synonym for antipyrine, 
31207— No. 23—05 2 
