41 
Character. — Colorless, lustrous, odorless crystals, having a sweetish, 
then somewhat bitter, taste. Its aqueous solution has an alkaline 
reaction to litmus. 
Solubility. — Easily soluble in water (1:1.5), less so in alcohol (1:10). 
In solution it is decomposed by dilute sulphuric acid with liberation 
of formaldehyde; it is precipitated by tannic acid and mercuric chloride. 
Dose. — “Average dose: 0.250 Gm. = 250 milligrammes (4 grains).” 
(U. S. P.) 
Caution. — It should be kept in well-stoppered bottles. 
Allied Compounds. — Hexamethylene-tetramine readily forms com- 
pounds with a large number of substances; among those suggested for 
use in medicine the following may be mentioned: 
Hexameth 3 denamine salic^date, urotropin salicylate^ or saliformin; a 
colorless, crystalline powder of nauseous, sweetish, astringent taste. 
Hexamethylenamine-ethylbromide, hromalhi, or hromoformin; a 
colorless, crystalline powder of a sweetish saline taste. 
Hexameth^denamine-tannin, tannopin^ or tannon; a brown tasteless 
powder, nearly insoluble in water and alcohol. 
Dioxybenzol-hexameth 3 denamine, lietralin^ contains 60 per cent of 
hexameth 3 denamine. 
Chinotropin and chinoformin are quinates of hexameth 3 denamine. 
Helmitol is a recentl 3 ^ introduced compound of hexameth 3 denamine with 
anhydrometh 3 dene citric acid. Citarin (sodium anhydrometh 3 dene 
citrate) is another compound from which formaldehyde is split off in 
the organism. 
HOMATROPINJE HYDROBROMIDUM. 
Homatropine Hydrobroiiiide. 
CifiH.iNOs.HBr 
Official under the same name in the British Pharmacopoeia; as Hom- 
atropinum hy^drobromicum in the German and Swiss Pharmacopoeias. 
“The hydrobromide of an alkaloid obtained by the condensation of 
tropine and mandelic acid.” 
Chemistry. — Atropine may be broken up, b 3 " the action of alkalies, 
into an alkaloid, tropine, and an aromatic acid, tropic acid. Tropine 
is a pyridine derivative having the structural formula 
CH,— CH CH, 
N(CH„) (*;hoh 
I I 
CH— CH CH, 
Tropine forms ester-like compounds with man 3 ^ acids; the compounds 
with aromatic acids are called tropeins. Homatropine is one of these 
tropeins; as stated above, it is formed by the union of tropine and 
mandelic acid; the latter is phen 3 dglvcollic acid 
