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pea. The vesicles soon rupture, leaving a small erosion which is soon 
covered by a thin crust under which the new formation of epithelium 
jDroceeds rapidly. The skin eruption mostly appears on the hands, 
tips of the fingers, base of the nails, volar surfaces of the finger tips, 
and more seldom on the toes and other parts of the body. Besides these 
local changes, during the course of the disease there are occasionally 
observed headache, pain in the limbs, vertigo, abdominal cramps, 
vomiting, diarrhea, and weakness. The disease is very seldom fatal, 
usually appearing in a very mild form except in weakened children 
in whom an accompanying intestinal catarrh may lead to a fatal 
termination. Those veterinarians who have had considerable experi- 
ence with this disease among animals regard the human affection as 
by no means uncommon in countries where foot-and-mouth disease 
prevails, but the disturbance of health is usually too slight to come 
to the notice of the family physician. The frequency of such infec- 
tion is established by numerous observations which have been recorded 
in the literature of foot-and-mouth disease, showing that human in- 
fection has constantly accompanied the outbreaks among cattle. Val- 
entin was probably the first to suggest the infectiousness of the milk 
and the transmissibility of the virus to man through the milk of dis- 
eased animals. He reported several cases where people became in- 
fected during the outbreak in Hesse in 1695. Sagar, in 1765, reported 
a similar infection of men in Moravia from drinking infected milk. 
In 1778 all the residents of an Austrian monastery developed a vesicu- 
lar eruption in the mouth after drinking virulent milk. Hertwig, 
Mann, and Villain conducted an experiment on themselves in 1831: 
by drinking milk warm from a cow which was suffering from an 
attack of foot-and-mouth disease. Five days later vesicles appeared 
on the hands, fingers, tongue, cheeks, and lips of Hertwig, while the 
eruption in the other two was confined to the buccal mucous mem- 
brane. 
Allbutt observed the vesicular eruption in the mouths of three 
children in Yorkshire during the English outbreak in 1883, and 
obtained information of a number of similar cases in the community. 
During the 1893 outbreak in Germany a shepherd infected himself 
by holding in his mouth a knife which had been used in paring the 
diseased feet of his sheep. A number of milkmaids were infected 
through milking, the vesicles ajopearing principally on their hands. 
A child fed on unboiled milk of affected cows developed an erup- 
tion of blisters on the tongue, lips, and soft skin between the fingers 
and toes. Furthermore, in the Berlin outbreak of 1895 a number 
of those who drank infected milk developed fever, followed by the 
formation of vesicles on the tongue and lips. The acute disease 
lasted about five days, leaving a feeling of great weakness for some 
time. Virchow made an investigation of these cases and unhesitatingly* 
