CONTENTS. 
Part I. Toxicity of Acetanilide Mixtures: Page. 
A . Summary 7 
B. Historical — 
1. Acetanilide-caffeine mixtures 8 
2. Acetanilide-sodium bicarbonate mixtures 10 
C. Determination of heart action— 
1. Action on frog’s heart — 
(a) Acetanilide-caffeine mixtures 13 
(&) Acetanilide-sodium bicarbonate mixtures 18 
2. Action on dog’s heart — 
(а) Acetanilide-caffeine mixtures 19 
(б) Acetanilide-sodium bicarbonate mixtures 27 
D. Determination of general toxicity — 
1. Hypodermic method — 
(a) Acetanilide-caffeine mixtures 27 
2. Feeding experiments on mice — 
(а) Acetanilide-caffeine mixtures 30 
(б) Acetanilide-sodium bicarbonate mixtures 36 
(c) Acetanilide and opium alkaloids 39 
{d) Acetanilide — salicylic-acid — bromides 42 
3. Feeding experiments on guinea pigs — 
(a) Acetanilide-caffeine mixtures 43 
(h) Acetanilide-sodium bicarbonate mixtures 45 
Part II. Toxicity op Antipyrine Mixtures: 
A . Determination of heart action — 
1. Action on frog’s heart 46 
2. Action on dog’s heart 48 
E . Determination of general toxicity — 
1. Hypodermic method — 
(a) Antipyrine-caffeine mixtures 50 
2. Feeding experiments on guinea pigs — 
(а) Antipyrine-caffeine mixtures... 52 
(б) Antipyrine-sodium bicarbonate 53 
C. Determination of toxicity of salijpyrine — 
1. Hypodermic method 54 
2. Feeding experiments 55 
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