26 
in Figure 6. Note also the great dilation of the heart as a late 
effect of acetanilide poisoning, both diastole and systole being 
much less complete as compared with the normal, a portion of 
which is also included in the cut. 
DETERMINATION OF GENERAL TOXIC ACTION. 
In view of the fact that the cases of acetanilide poisoning are due 
to an involvement of all the vital organs of the body and not on 
account of its heart action alone, a series of experiments was carried 
out to determine what modification of the general toxicity could be 
secured by administering it to intact animals with the drugs com- 
monly found in acetanilide mixtures. In these experiments the 
drugs were administered to white mice by hypodermic injection and 
to mice and guinea pigs by the stomach. 
