2S 
As a means of control the following experiments were carried out 
to determine the fatal dose of 55 per cent alcohol: 
Txble IX . — Ddurmmation of mmimum Jdhal dcm of 65 per cent aJeohol for trMte mite. 
Dose ealmlaied in terms of grams of aeetanUide for sate of torn par ison. 
=STiurviT>ei!i; -r-=<ifeaila.] 
‘gTAnbo'ij Eesniliii- 
HcKnrs 
iS 
mss 
(Ol — 
. s>M>5 — 
S^ri*?s It . 
-^c« 
— 
35. 
-Ctr4 - 
35-65 
.([itiitS — 
3 
S^rf^ m . 
3)L@!)I 
. NjllltSO' — 
-CDei - 
. njl'jeS’ — 
6 
The minimum lethal dose for caheine citrate was determined in 
the same manner, excepting that the drug was dissolved in physio- 
logical salt solution. The dc^e just stifficient to cause death was 
found to be 0.0007 gram. 
The results of this series of experiments are fotmd in Table X. 
Table X.- — Determination of the minimum lethal dose of eamine citrate for white mice. 
hypodermic injection. 
I — =SCTTire<'i; — =iie3'!u!]i.J, 
is jnrasLS- 
Iloeeper ! 
grsmL tiiMiv : 
Kesslir- tail 
1 (fesSSl. 
!■ 
13- T2 i 
0. Wu5 
M-3& 1 
13.3S 1 
12. -51 
. 1'ilA‘S ‘ 
■ .(iHM i 
, . I'jiHiriip. 
Z A 
1 
16. St? 
12. -52 
14.4(5 
■ . ' jii>V 
. '■jiOi'jtt- 
- 
M.«j2 
. "jijiV-S 
— 5l 
Having thus determined the minim um fatal dose for acetanilide 
and caiieine citrate, both drugs were mixed in Viirying proportions, 
dissolved in 55 per cent alcohol, and injected in the manner as in the 
previous experiments. A series of mice were injected with mix- 
tures containing 0.0012 of acetanilide and 0.0001 and 0.0002 gram 
of caSeine per gram of body weight, but this dosage proved to be 
invariably fatal, thus proving the absence of any antidotal proper- 
ties for caheine in the above amounts. A further series of experi- 
ments was then carried out. using smaller amounts of acetanihde to 
determine whether the effect might not represent a summation of the 
tr.xic action of the two drugs. In estimating the doses to be given 
the fatal doses of each drug, as already determined, were added 
