32 
Having determined the period which mice fed on the simple drugs, 
a series of mice were fed upon a mixture of these drugs with the fol- 
lowing results: 
Series I. — Acetanilide-caffeine. 
[Feeding mice acetanilide 0.050 gram+cafieine citrate 0.020 gram per cake.] 
Date. 
Weight of mice in grams. 
1. 
1 
2. 
3. 
4. 
1908. 
December 3 
14.71 
11.70 
15.42 
12.64 
11.75 
14.16 
11.97 
12. 50 
14. 20 
11.77 
12. 06 
11.51 
December 5 
December 7 : 
December 9 
No. 1, dead December 7 , 4 days; No. 2, dead December 8, 5 days; No. 3, dead December 8, 5 days; 
No, 4, dead December 10, 7 days. 
A somewhat decreased toxicity was observed when smaller amounts 
of caffeine were given. The results are tabulated below: 
[Feeding mice acetanilide 0.050 gram+caffeine citrate 0.010 gram per cake.] 
Date. 
Weight of mice in grams. 
1. 
2. 
3. 
4. 
1908. 
December 3 
16.29 
13.39 
16. 53 
13.71 
13. 09 
17.41 
14. 08 
13. 08 
11.00 
14. 42 
12. 25 
11.02 
9. 73 
December 5 
December 7 
December 9 
12. 79 
No. 1, dead December 7, 4 days; No. 2, dead December 10, 7 days; No. 3, dead December 10, 7 days; 
No. 4, dead December 11, 8 days. 
In the following tables are given the results of a later series of 
experiments. Control mice fed caffeine citrate 0.040 gram lived a 
somewhat shorter time than in the previous series, namely, 13, 34,35, 
and 40 days. The table showing this control may be omitted, since 
the relative small degree of toxicity of this drug in this dose is appa- 
rent in the above figures. The protocols of control mice fed on 
simple acetanilide cakes and mice fed on a mixture of acetanilide 
and caffeine are to be found in the following tables : 
Series II. — Control: Acetanilide. 
[Feeding mice acetanilide 0.050 gram per cake.] 
Date. 
Weight of mice in gram.s. 
1. 
2. 
3. 
4. 
1909. 
February 11 
18.34. 
15. 43 
13. 67 
14. 15 
20. 78 
17. 80 
15. 80 
14. 23 
18. 92 
15. 59 
14. 06 
13. 26 
20. 00 
17. 29 
14. 44 
12. 65 
10. 80 
February 13 • 
February 15 
February 17.. 
Fp.brnnry 20 
No. 1, dead February 18, 7 days; No. 2, dead February IS, 7 days; No. 3, dead February 19, 8 days; 
No. 4, dead February 21, 10 days. 
