36 
[Feeding mice acetanilide 0.050 gram + caSeine citrate 0.010 gram + sodium bicarbonate 0.020.] 
Weight of mice in grams. 
Date. ^ ^ ^ 
> Xo. 1. Xo. 2. Xo. 3. Xo. 4. 
Days. Days. Days. Days. 
Decembers 16.39 16.16 14.92 18.40 
Decembero 14.06 : 13.47 12.06 
December? 13.48 12.44 11.86 
December 9 - 12.95 13.80 
December 13 13.65 
December 15 12.54 
December 17 13.57 
Xo. 1, dead December 17, 14 days; Xo. 2, dead December 11, 8 days; Xo. 3, dead December 9, 6 days; 
Xo. 4, dead December 5, 2 days*. 
In a later series of experiments sodium bicarbonate was mixed 
with acetanilide, the caheine being omitted. The results of experi- 
ments of this sort are tabulated below: 
Series II axd IV . — Acetamlide and sodium hicarhonaie. 
[Feeding mice acetanilide 0.050 gram -f sodium bicarbonate 0.020 gram per cake.] 
Weight of mice in grams. 
Date. 
Xo. 1. Xo. 2. Xo. 3. Xo. 4. 
1909. Days. Days. Days. Days. 
February 11 21.50 21.61 22.68 18.52 
February 13 18.50 18.23 20.10 16.02 
February 15 16.95 16.10, 16.84^ 14.50 
February 17 15.90 14.71 1 15.42 j 13.46 
February20 14.50 13.80 ; ‘ 
March 15 1.5.82 17.58 17.30 i 19.18 
March 18 13.66 16.51 16.00 16.18 
March 20 12.03 14.10 13.73 13.82 
March 22 10.73 12.15 12.50 13.43 
March 24 10.70 11.44 11.50 
March 26 - 10.41 10.55 -..V 
Xo. 1, dead February 21, 10 days, and March 28, 13 days; Xo. 2, dead February 21. 10 days, and March 
27, 12 days; Xo. 3, dea'd February 20, 9 days, and March 25, 10 days; Xo. 4, dead February 19, 8 days, 
and March 24, 9 days. 
As a control for Series IT mice were fed on acetanilide 0. 050 per 
cake and lived for 7, 7, 9, and 13 days, respectively. 
To determine whether a larger amount of the carbonates would 
still further lessen the toxicity, a series of mice were fed cakes each 
containing 0.040 gram sodium bicarbonate. Again this mixture 
showed the antidotal action of an alkali carbonate, and while this 
is somewhat greater with the increase of alkali the figures do not 
indicate any special advantage. The averages are given in the fol- 
lowing table: 
Series. 
Acetamhde 0.050. 
Acetanilide 0.050, 
XaHCOs 0.020. 
Acetamhde 0.050, 
XaHCOs 0.040. 
II^IV 
Days. \ 
Day.3. ( 
Days. 
8.50 
10. 10 
Adyantage 1. CO 
m 
7.00 
8. 75 
Adyantage 1. 75 
