37 
The following summaries are arranged in order to bring the results 
of these experiments together for the sake of comparison: 
SUMMARY. 
Series. 
Control. 
Acetanilide 
mixture. 
Caffeine 0.020, 
NaHCOs 0.020. 
Acetanilide 0.050. 
Acetanilide 0.050, 
NaHCOs 0.020. 
II i 
IV ' 
Average j 
Days. 
\ " 
\ 35 
[ 36 
|;;eeee; 
Days. 
7 
7 
8 
1 10 
7 
7 
i 9 
i 13 
Days. 
8 
9 
10 
10 
9 
10 
12 
13 
30. 75 : 
8.50 
10. 10 
comparing the results as given in the above summary it will 
be noted that in the case of mice sodium bicarbonate is antagonistic 
to acetanilide to a certain degree in the general average of the two 
series, as 8.50 is to 10.10. This same antagonism is also shown in 
the experiments in which caffeine was also a constituent of the 
mixture, a summar}^ of which is given below: 
SUMMARY. 
Series. 
Control. j 
Acetanilide mixture. 
Acetanilide 
0.050. 
Acetanilide 0.050, 
caffeine 0.020. 
Acetanilide 0.050, 
caffeine 0.010. 
Acetanilide 0.050, 
caffeine 0.020, 
NaHCOs 0.020. 
Acetanilide 0.050, 
caffeine 0.010, 
NaHCOs 0.020. 
Days. 
Days. 
Days. 
1 Days. 
Days. 
4 
4 
! 3 
2 
T 
I 5 
5 
7 
i 6 
6 
i 
1 ^ 
5 
7 
I 6 
8 
1 20 
7 
8 
7 
14 
Average. . 
8.75 
5. 25 
6. 50 
5. 50 
7.50 
These results do not show quite so marked antagonism between 
acetanilide and sodium bicarbonate as is shown by the results given in 
the preceding summary. Their agreement serves, nevertheless, as 
very valuable contributory evidence of the lessened toxicity of a 
mixture of acetanilide containing sodium bicarbonate. It will be 
observed, however, that despite some antidotal action this is still 
insufficient to make acetanilide mixtures containing caffeine as non- 
toxic as those which omit it entirely. This is illustrated by the 
following data, the averages of series No. I, II, and III: 
Acetanilide 0.05. 
Acetanilide 0.05, 
caffeine 0.02. 
Acetanilide 0.05, 
caffeine 0.02, 
NaHCOs 0.02. 
Acetanilide 0.05, 
NaHCOs 0.02. 
General average 
7.91 
4.75 
5. 50 
10.10 
