38 
This may be represented gTaphically as follows : 
The degree of toxicity being represented by the length of the bars. 
Acetanilide, 
NaHCOs 
Acetanilide 
Acetanilide, caf fe- 
ine, NaHCOa 
Acetanilide, caffe- 
ine 
i 
TOXICITY OF ACETANILIDE AND THE OPIUM ALKALOIDS. 
Experiments were carried out upon white mice to determine the 
toxicity of mixtures composed of acetanihde and codeine and acetani- 
lide and morphine. Control mice were fed morphine sulphate 0.002 
gram per cake lived 20, 27, 36, and 45 da^^s. Controls of codeine-fed 
mice lived 10, 29, 61, and 65 days. As in the previous experiments 
where the results of the same series have been recorded, the acetani- 
lide controls vdll not be given again except as data to complete the 
summary of these experiments. 
Series II. — Acetanilide- coddne. 
[Feeding mice acetanilide 0.050, codeine 0.010 gram per cake.] 
Date. 
Weight of mice in grams. 
1. 
2. 
3. 
4. 
1909. 
February 11 
22. 85 
20. 34 
18. 74 
16. 38 
16. 18 
14. 69 
15. 20 
12. 86 
10. 98 
9.59 
9. 36 
•17. 08 
14. 47 
14. 38 
12. 16 
11.74 
15.88 
13. 25 
11.31 
9. 30 
8.92 
February 13 
February 15 
February 17 
February 20 
February 24 
No. 1, dead February 26, 15 days; Xo. 2, dead February 23, 12 days; No. 3, dead February 21, 10 days; 
No. 4, dead February 21, 10 days. 
[Feeding mice acetanilide 0.050, codeine 0.005 gram per cake.] 
Date. 
Weight of mice in grams. 
1. 
2. 
3. 
4. 
1909. 
February 11 
15. 48 
14. 55 
12. 02 
11.19 
10. 38 
19. 34 
16.63 
13.88 
11.93 
10. 48 
17. 06 
15. 42 
13.10 
12. 05 
14. 48 
13.62 
12. 34 
February 13 
February 15 
February 17 . 
February 20 
No. 1, dead February 21, 10 days; No. 2, dead February 21, 10 days; No. 3. dead February 20, 9 days; 
No. 4, dead February 16, 5 days. 
A summary of the results of this series is given in the following 
table to make the comparison of the toxicity easier. 
