39 
SUMMARY^ 
Series. 
Control. 
Acetanilide mixtures. 
Codeine, 0.010. 
i 
Acetanilide, 0.050. 
j 
Acetanilide, 0.050, 
codeine, 0.005. 
Acetanilide, 0.050, 
codeine, 0.010. 
II 
Days. 
10 
I 29 
61 
i 65 
Days. 
7 
8 
10 
Days. 
5 
9 
10 
10 
Days. 
10 
10 
12 
15 
Average 
41.25 j 
8.00 
8. 50 
11.75 
The data shown in this summary indicates that codeine is anti- 
dotal to the general toxic effects of acetanilide. This result was 
rather unexpected, but the fact that the mice receiving the larger 
dose of codeine in combination with acetanilide lived the longer 
served to confirm these findings. The number of mice fed upon 
mixtures of this sort was too small however to give results from 
which to draw absolute conclusions and accordingly a further series 
of mice were fed, using heroine and morphine in addition to codeine. 
The results of these experiments are given in the following tables. 
Control « acetanilide. 
[Feeding mice acetanilide 0.050 gram per cake.] 
a The control mice receiving 0.010 gram codeine, 0.002 gram morphine sulphate, and 0.00075 gram heroine 
hydrochloride are still alive at this date (April 29, 1909). 
No. 1, dead April 28, 11 days; No. 2, dead April 27, 10 days; No. 3, dead April 27, 10 days; No. 4, dead 
April 24, 7 days. 
In the following table the protocols of mice fed upon acetanilide 
and codeine are given: 
Series V. — Acetanilide-codeine. 
[Feeding mice acetanilide 0.050 gram plus codeine 0.010 gram per cake.] 
Weight of mice in grams. 
Date. 
1. 
2. 
3. 
4. 
1909. 
April 17 
17.73 
14. 75 
13. 45 
12.62 
10. 86 
20. 67 
16. 63 
15. 43 
14.24 
18. 57 
15. 71 
14.08 
12.28 
22.31 
17.85 
16. 76 
April 19 
April 21 
April 93 
April 26 
No. 1, dead April 27, 10 days; No. 2, dead April 24, 7 days; No. 3, dead April 23, 6 days; No. 4, dead 
April 23, 6 days. 
