43 
Control experiments with caffeine citrate gave the following 
results : 
[CafEeme control: Determination of the minimum lethal dose of caffeine citrate for giimea pigs. — = 
survived; += death.] 
Weight 
in 
grams. 
Dose per 
gram weight 
in grams. 
Result. 
Hours 
till 
death. 
530 
0. 0003 
480 
.0004 
— 
495 
.0004 
j — 
405 
. 0004 
1 + 
16 
435 
.00045 
I 
415 
.0005 
— 
410 
.0005 
— 
565 
.0005 
+ 
15 
405 
.00055 
+ 
15 
415 
.0006 
+ 
In like manner a series of guinea pigs were given pills containing 
acetanilide and caffeine citrate. The results of these experiments are 
tabulated below: 
Acetanilide-caffeine Determination of the minimum lethal 
dose of a mixture of acetanilide and caffeine citrate. 
[— = survived; += death; A = acetanilide; C=caffeine citrate.] 
Weight 
Dose per 
Hours- 
1 
gram weight 
Result. 
till 
grams. 
in grams. 
death. 
555 
f AO. 0006 
1 - 
\ C . 0002 
/ A . 0006 
i 
\ 
545 
\ C . 0003 
/ 
i 
580 
/ A . 0008 
\ C . 0002 
1 
520 
/ A . 0008 
\ C . 0003 
1 - 
600 
/ A . 0010 
\ C . 0002 
} - 
21 
380 
/ A . 0010 
\ C . 0002 
} - 
13 
460 
/ A . 0010 
\ C . 0003 
I - 
17 
350 
/ A . 0012 
\ C . 0002 
} - 
20 
425 
/ A . 0012 
\ C . 0003 
} - 
112 
385 
( A .0014 
\ C . 0002 
} - 
HlCi 
CO 
450 
J A . 0014 
\ C . 0003 
} - 
m 
The minimum lethal dose of acetanilide for guinea pigs appears by 
these experiments to be approximately 0.0013 gram and that of 
caffeine citrate about 0.00055. The mixture of caffeine (caffeine 
about one-third of the least fatal dose) and acetanilide shows an 
increased toxicity, a dose of 0.0010 gram acetanilide in a mixture 
with caffeine being sufficient to invariably cause death instead of 
0.0013 gram per gram of body weight, as is the case when given 
