u 
alone. These results serve to confirm the results of the feeding 
experiments upon nfice and show very clearly the abs?nce of any 
antagonistic action. 
TOXICITY OF ACETANILIDE AND SODIUM BICARBONATE. 
Experiments using equal parts of acetanilide and sodium bicar- 
bonate were carried out in the same manner as the above experi- 
ments. The animals used in this series had been given acetanihcLe 
a week previously and had apparently recovered. In the controls 
for tins series a smaller fatal dose showed that they were more 
susceptible^ however , than in the earher experiments, death invariably 
resulting from 0.0011 gram per gram of body weight. The pigs 
receiving the mixture containing sodium bicarbonate were somewhat 
more resistant, with one exception, the least fatal dose appearing 
to be approximately 0.0014 gram per gram of body weight, thus indi- 
cating that the carbonates are antagonistic to acetanilide to a certain 
extent. These experiments are tabulated below. 
ACETANILIDE-SODIUM BICARBONATE. 
[Deterrniiiation of The lethal dose of a mixture of acetanilide and sodium hic-arbonate. — = surrived; 
— = death; A = acetanilide; S = sodium bicarbonate,] 
in grams. 
365 
3S0 
340 
Dose per 
gram tteight 
in grams. 
Eesult. 
Hours 
tUl 
death. 
/ 
A 0. 0010 
\ . 
36 
1 
s 
.0010 
J 
f 
A 
.0012 
s 
.0012 
i 
J 
A 
.0014 
i 
s 
.0014 
J 
A 
.0014 
1 
13-V 
i 
s 
.0014 
)' 
/ 
A 
.0015 
\ . 
4 
s 
.0015 
1 ^ 
OU 
4 
A 
.0016 
1 
74 
.0016 
f ■ 
The lessened toxicity of this mixture was fimther confirmed by 
comparing the duration of hie imder the same dosage either of the 
simple remedy or the mixture. The time guinea pigs hved after 
increasing doses of acetanfiide alone was 20, 4f, 21, 9J, 44, 13, and 
26| hours. Pigs receiving corresponding doses of the mixture hved 
36. 134, 50, 7f . 134, 15, and 18 hours. The sum of the hours of dura- 
tion of life after dosage therefore is OOpg for the simple remedy: 153j 
hours for the mixture. Pather httle emphasis is intended for this 
point, however, because of the great irregularity m the time the 
animals hved, as will be noted in the above figures, which are arranged 
in order of the increase hi amount of dmg given. 
