53 
TOXICITY OF ANTIPYRINE AND SODIUM BICARBONATE. 
Guinea pigs were given doses of equal parts of antipyrine and 
sodium bicarbonate to see whether any antagonism, as was apparent 
in the case of acetanilide, could be developed. The control experi- 
ments using antipyrine alone are tabulated on the preceding page. 
No controls using sodium bicarbonate were thought necessary on 
account of its nonpoisonous character. The results of the experi- 
ments using the mixture of antipyrine and sodium bicarbonate are 
tabulated below. 
[Antipyrine and sodium bicarbonate: Determination of the minimum lethal dose for guinea pigs of a mix- 
ture of antipyrine and sodium bicarbonate. —Survived; + death; A, antipyrine; S, sodium bicar- 
bonate.] 
! 
Weight 
Dose per 
Result. 
Hours 
till 
in grams. 
gram. 
death. 
315 
/ A 0.0012 
\ S .0012 
1 - 
/ 
1 _ 
365 
1 A .0012 
X S .0012 
/ 
485 
( A .0014 , 
\ S .0014 ! 
'} + 
18 
420 
A .0014 
\ S .0014 
} - 
15 
445 
j A .0016 
1 S .0016 
} - 
9 
355 
/ A .0016 
\ S .0016 
il + 
8 
These protocols indicate that a mixture containing sodium bicar- 
bonate is of approximately the sam.e toxicity as antipyrine given 
alone, the minimum lethal dose being 0.0014 gram per gram body 
weight in each case. A lessened toxicity is suggested by the longer 
period of life after equivalent doses of the mixture, but at best this is 
so slight as to be almost negligible. 
SALIPYRIN. 
Salipyrin, a chemical combination of antipyrine and salicylic acid, 
was made the subject of a further series of experiments in order 
to compare its toxicity with a simple mixture of antipyrine and sali- 
cylic acid when given in the same proportions as occurs in the chem- 
ical compound. Special interest in this comparison was stimulated 
by the abstracts and reprints sent out by the American firm selling 
this product, since these invariably point out ids nontoxic character. 
These may be abstracted as follows: 
Lohman® reported that it was more active than its components 
and was free from the secondary action so often observed after anti- 
a Lohman, Deutsch. med. Ztg., 1903, XXIV, 1142. 
