54 
pyrine. Lubowski^ stated that there was complete absence of 
secondary effects such as are common when its components are used. 
According to Buettner^ the dangerous heart effect of antipyrine is 
avoided by its administration as salipyrin. Muhlbauer'' reported 
no bad effects subsequent to a dose of 1 0 grams of the drug. 
In entire disagreement to these reports a large number of others 
have appeared reporting the deleterious effects from the use of salipyrin 
even in small doses. The symptoms generally present were various 
skin eruptions, burning in the region of the stomach, profuse sweating, 
dilated pupils, great air hunger, marked heart distress, and fear of 
impending death. In Dumstrey’s cases these symptoms appeared 
after 1 gram of the drug had been taken. 
As will be recognized, these are the ordinary symptoms associated 
with antipyrine or with salicylic acid poisoning, and they certainly 
do not bear out the statements found in the advertising literature as 
to the absence of toxic and secondary symptoms. From the com- 
paratively large number of cases of poisoning it would seem probable 
also that the salipyrin was fidly as toxic as a simple mixture of its 
components. Theoretically also this would seem probable, since -.his 
compound is broken up in the body into its constituents,^ and it 
would therefore produce an effect in the body similar to that of the 
two drugs from which it is compounded. 
In proof of this pouit the following experiments were carried out to 
determine the relative toxic values for animals of salipyrin and of a 
mixture composed of antipyrine and salicylic acid in the same pro- 
portions as occur in the chemical compound. In the first series of 
experiments the drugs were injected beneath the skin of the back of 
white mice. Mice belonging to the same lot and kept under the same 
conditions were weighed and the dose given was estimated upon the 
basis of grams of body weight. On account of the insolubility of 
salip}win and sahcylic acid in water it was found necessary to dissolve 
the drugs in 50 per cent alcohol in such amounts that 1 c. c. of the 
solution represented 100 milligrams of salipyrin in one case and 57.7 
milligrams antipAwine and 42.3 milligrams of salicylic acid, the pro- 
portionate amount of these drugs entering into the compound, in the 
other. The amount of alcohol injected in this way is so small that the 
chief symptom from it was merely some unsteadiness in the animaks 
« Lubowski, Allg. med. Centr.-Ztg., 1903, LXXII, 682. 
& Buettner, Cor. Bl. f.-schweiz. Aerzte, 1900, XXX. 
c Mublbauer, Wien. med. Wocbenschi-., 1897, XL VII, 196. 
<?Scbmey, Therap. Monatshefte, 1897, XI, 175. Dumstrey, Deutsche med. Woch- 
enschr., 1903, XXIX, 461. Dittmer, Med. Woche, 1903, IV, 579. Scharfe, Therap. 
Monatshefte, 1903, XVII, 163. Bitter, Berl. klin. Wochenschr.. 1908, XLV, 338. 
«CtLshny, Pharmacology and Therapeutics, 1906, p. 380. 
