i 
56 
as judged by the time the animals survived the introduction of the 
drug. The results are as follows : 
Series I. 
[Protocols of experiments to determine relative toxicity of saiipyrin and of a mixture of antipyrine and 
salicylic acid when given to guinea pigs by the stomach. — =survhed; +=death.] * 
[SaUpyrin.] 
Weight. 
Dose. 
Hours 
Ptesult. till 
, death. 
620 
0. 0016 
+ 1 12 
480 
.0016 
+ 1 9 
470 
.0016 
— 
450 
.0016 
— ! 
430 
.0016 
— 
470 
.0016 
“ 
[Antipyrine 57.76 +salicy lie acid 42.3 per cent.] 
530 
0.0016 
470 
.0016 
610 
.0016 
490 
.0016 
Series II. 
[Saiipyrin.] 
Weight. 
Dose. 
Result. 
Hours. 
till 
death. 
530 
0.0018 
+ 
3.30 
405 
.0018 
+ 
5 
410 
.0018 
+ 
6 
420 
.0018 
+ 
14 
[A. and S. mixture.] 
455 
0.0018 
+ 
2.30 
405 
.0018 
+ 
3.30 
505 
.0018 
+ 
5 
430 
.0018 
+ 
26 
Feeding experiments were carried out on white mice, using the 
method already described for acetanilide, page 29. Each cake con- 
tained 0.100 gram saiipyrin as a control; the cakes made up with the 
simple mixture each contained 0.0577 gram antipyrine and 0.0423 
gram salicylic acid. In other words, the control cakes contained 
just the same proportionate amount of the two drugs as did those 
containing the mixture. 
The feeding of these cakes to mice obtained from the same lot was fol- 
lowed by a slow but equal decrease in weight, and the duration of life in 
the case of the mice receiving the mixture and those receiving the same 
