57 
amount of drugs chemically combined was approximately the same. 
The protocols taken from these experiments are as follows: 
Control^ salipyrin. 
[Feeding mice salipyrin 0.100 gram per cake. — = survived; + = death.] 
Weight of mice, in grams. 
Date. 
1909. 
February 13 
February 17 
February 20 
February 24 
February 27 
narch 1 
ifarch 3 
March 6 
March 9 
March 11 
No. 1. 
No. 2. 
No. 3. 
No. 4. 
19.84 
18.36 
18.08 
17.71 
19.19 
17.16 
16.70 
17.05 
20.12 
18.50 
18. 47 
16.76 
19.30 
17.74 
18. 08 
16.10 
18.89 
17.30 
16.99 
14.65 
17. 40 
16.34 
15. 45 
14. 30 
15.99 
15.19 
15. 23 
13.30 
13.95 
15.62 
14. 85 
15. 57 
14.76 
14.02 
14.14 
No. 1, dead March 2, 27 days; No. 2, dead March 11, 26 days; No. 3, dead March 7, 22 days; No. 4, dead 
March 6, 21 days. 
In hke manner a series of mice were fed upon a mixture of anti- 
pyrine and sahcyhc acid given in the same proportions in which they 
combine and form sahpyrin. The results of these experiments are 
given below. 
Antipyrine-salicylic acid mixture. 
[Feeding mice antipyrine, 0.0577 gram plus salicylic acid 0.0423 gram per cake.] 
February 13. 
February 17. 
February 20. 
February 24. 
February 27. 
March 3 
March 6 
March 9 
Weight of mice, in grams. 
Date. 
No. 1. No. 2. No. 3. No. 4. 
22.51 
19. 75 
16.15 
20.04 
21. 19 
18. 92 
15.71 
19. 70 
22. 09 
18. 46 
15. 81 
18. 30 
21.54 
16. 86 
14.50 
18. 38 
20. 34 
16. 01 
14. 40 
16.85 
18. 36 
14.28 
13. 39 
16. 30 
16.57 
13.48 
12.62 
16. 08 
13.92 
No. 1, dead March 10, 25 days; No. 2, dead March 10, 25 days; No. 3, dead March 7, 22 days; No. 4, dead 
March 5, 20 days. 
The average duration of hfe for mice fed sahpyrin was twenty-four 
days; for mice receiving the mixture, twenty-three days — a differ- 
ence that is quite neghgible in experiments of this sort, on account of 
the small toxic action of the drugs used. 
In conclusion, it may be said that the results of the whole series of 
experiments indicate no change in the toxicity of a mixture of anti- 
pyrine and sahcyhc acid when formed into a definite compound by 
chemical means. 
